Synthesis of 2-Fluoroalkylated Oxazoles from β-Monosubstituted Enamines Fluoroacyloxylation and Cyclization Mediated by Fluoroalkyl-Containing Hypervalent Iodine(III) Species Generated .

A metal-free synthesis of a series of fluoroalkyl-containing oxazoles from β-monosubstituted enamines was developed. This fluoroacyloxylation/cyclization cascade process was mediated by fluoroalkyl-containing hypervalent iodine(III) species formed from the reaction of phenyliodine(III) diacetate (PIDA) and RCFCOH (R = H, Cl, Br, F, CF, CH, Ph, SAr, OAr).