A simple and efficient electrochemical method that utilizes modulation of the cell voltage to cause structural alterations in 2-indazole is introduced. This method enables the C-3 acyloxylation of 2-indazole and promotes the transfer of the acyl group from C-3 to N-1, allowing the N-acylation of 2-indazoles. Additionally, the application of the μ-electro flow reactor was demonstrated, showcasing its effectiveness in achieving gram-scale production of within a short residence time.
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| http://dx.doi.org/10.1021/acs.orglett.3c01649 | DOI Listing |
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