Calcium-permeable AMPA receptors: an underestimated pharmacological target for the therapy of brain pathologies.

Neural Regen Res

Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino, Russia.

Published: December 2023

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358676PMC
http://dx.doi.org/10.4103/1673-5374.373714DOI Listing

Publication Analysis

Top Keywords

calcium-permeable ampa
4
ampa receptors
4
receptors underestimated
4
underestimated pharmacological
4
pharmacological target
4
target therapy
4
therapy brain
4
brain pathologies
4
calcium-permeable
1
receptors
1

Similar Publications

3,4,5-trimethoxycinnamic acid methyl ester isolated from Polygala tenuifolia enhances hippocampal LTP through PKA and calcium-permeable AMPA receptor.

Biochem Pharmacol

December 2024

Department of Advanced Translational Medicine, Graduate School, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea; Department of Pharmacology, College of Medicine, Konkuk University, Chungju 27478, Republic of Korea; Institute of Biomedical Sciences & Technology, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

Alzheimer's disease (AD) is a degenerative brain disorder characterized by progressive cognitive decline and neuronal death due to extracellular deposition of amyloid β (Aβ) and intracellular deposition of tau proteins. Recently approved antibody drugs targeting Aβ have been shown to slow the progression of the disease, but they have minimal effects on cognitive improvement. Therefore, there is a need to develop drugs with cognitive-enhancing effects that can be used in conjunction with these antibody treatments.

View Article and Find Full Text PDF

The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds.

Front Pharmacol

October 2024

Laboratory for the Research of the Mechanisms of Regulation and Compensation of Nervous System Excitability Pathologies, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, Saint Petersburg, Russia.

Amidine-containing compounds are primarily known as antiprotozoal agents (pentamidine, diminazene, furamidine) or as serine protease inhibitors (nafamostat, sepimostat, camostat, gabexate). DAPI is widely recognized as a fluorescent DNA stain. Recently, it has been shown that these compounds also act as NMDA receptor inhibitors.

View Article and Find Full Text PDF
Article Synopsis
  • AMPA receptors (AMPARs) play a key role in fast brain signaling, responding to glutamate, with a focus on calcium-permeable versions known as CP-AMPARs, influenced by auxiliary proteins.
  • This review highlights the importance of these auxiliary subunits in modifying AMPAR function and their relationship to cognitive processes like learning and memory.
  • Changes in these auxiliary proteins are linked to various neurological disorders, and targeting them could lead to new treatment options for complex brain conditions.
View Article and Find Full Text PDF

The brain helps us survive by forming internal representations of the external world. Excitatory cortical neurons are often precisely tuned to specific external stimuli. However, inhibitory neurons, such as parvalbumin-positive (PV) interneurons, are generally less selective.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!