Molecular epidemiology of antibiotic-resistant among clinical samples isolated in Azerbaijan, Iran.

Background And Objectives: The immediate emergence of resistant bacteria poses an increasingly growing problem to human society and the increasing prevalence of antibiotic resistance in strains is one of the most important health problems. This study aimed to review the molecular epidemiology of drug resistance among clinical isolates of in north-west portion of Iran Azerbaijan.

Materials And Methods: A complete of 219 clinical isolates of had been collected from the various clinical samples. The disk diffusion and agar dilution assays were used to determine antimicrobial susceptibility. The presence of antibiotics resistance genes was carried out by the PCR method.

Results: The highest susceptibility was shown to imipenem (3%) and fosfomycin (3%), and the most antibiotic resistance was presented to ampicillin (99%). The highest frequent ESBL gene among isolates was in 70% followed by in 67%, and in 46%. The most common fluoroquinolone (FQ) resistance genes were (34%), followed by (25%), and (18%). The frequency of tetracycline resistance genes ( and ) were detected in 24.8%, 31.6%, 1.8%, and 4.2%, respectively. The highest frequent genes to fosfomycin were 10%, 30%, 40%, and 20%. The dominant founded aminoglycosides resistant genes were (12.96%) and (4.93%).

Conclusion: The prevalence of antibiotics resistance in the tested isolates was high in Azerbaijan, Iran and these findings showed that is one of the major drug-resistant pathogens.