AI Article Synopsis

Article Abstract

This study evaluated the cholesterol-alleviating effect and underlying mechanisms of chitosan-oligosaccharide (COS) in hypercholesterolemic hamsters. Male hamsters ( = 24) were divided into three groups in a random fashion, and each group was fed one particular diet, namely a non-cholesterol diet (NCD), a high-cholesterol diet (HCD), and an HCD diet substituting 5% of the COS diet for six weeks. Subsequently, alterations in fecal bile acids (BAs), short-chain fatty acids (SCFAs), and gut microflora (GM) were investigated. COS intervention significantly reduced and increased the plasma total cholesterol (TC) and high-density lipoprotein-cholesterol (HDL-C) levels in hypercholesteremic hamsters. Furthermore, Non-HDL-C and total triacylglycerols (TG) levels were also reduced by COS supplementation. Additionally, COS could reduce and increase food intake and fecal SCFAs (acetate), respectively. Moreover, COS had beneficial effects on levels of BAs and GM related to cholesterol metabolism. This study provides novel evidence for the cholesterol-lowering activity of COS.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346597PMC
http://dx.doi.org/10.3390/nu15132923DOI Listing

Publication Analysis

Top Keywords

hypercholesterolemic hamsters
8
gut microflora
8
bile acids
8
short-chain fatty
8
fatty acids
8
cos
7
diet
5
marine chitosan-oligosaccharide
4
chitosan-oligosaccharide ameliorated
4
ameliorated plasma
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!