Phragmalin-Type Limonoids from the Fruits of and Their Anti-Inflammatory Activity.

Phytochemical investigation on the fruits of led to the isolation of five new phragmalin-type limonoids (-) and four known ones (-). The structures of the new compounds -, named chuktabamalins A-E, were elucidated via spectroscopic techniques (HRESIMS, 1D and 2D NMR) and were comparable with the literature data of known compounds. In addition, new compounds were evaluated for in vitro anti-inflammatory activity. Compounds , , and showed moderate anti-inflammatory activity with IC values of 21.72 ± 2.79, 23.29 ± 1.00, 47.08 ± 3.47 and 66.67 ± 2.89 μM, respectively.