AI Article Synopsis
- The study focuses on the stability of magnetic iron oxide nanoparticles in various physiological fluids, which is essential for their use in medical applications.
- Researchers evaluate the colloidal stability of commercially available nanoparticles and compare them to biogenic nanoparticles (magnetosomes) from magnetotactic bacteria.
- Stability is assessed using dynamic light scattering to measure particle size, which serves as a quality criterion and can indicate the formation of a protein corona around the nanoparticles.
Article Abstract
For the potential in vitro/in vivo applications of magnetic iron oxide nanoparticles, their stability in different physiological fluids has to be ensured. This important prerequisite includes the preservation of the particles' stability during the envisaged application and, consequently, their invariance with respect to the transfer from storage conditions to cell culture media or even bodily fluids. Here, we investigate the colloidal stabilities of commercial nanoparticles with different coatings as a model system for biogenic iron oxide nanoparticles (magnetosomes) isolated from magnetotactic bacteria. We demonstrate that the stability can be evaluated and quantified by determining the intensity-weighted average of the particle sizes (-value) obtained from dynamic light scattering experiments as a simple quality criterion, which can also be used as an indicator for protein corona formation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343720 | PMC |
| http://dx.doi.org/10.3390/molecules28134895 | DOI Listing |
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