AI Article Synopsis
- This study explored the impact of retinoblastoma and its treatments on children's vision, specifically focusing on contrast sensitivity and saccades (eye movement).
- Eleven children aged 5-17 years who completed treatment were assessed for visual acuity, saccades, and contrast sensitivity.
- Results showed that all tested participants had decreased saccade parameters and impaired contrast sensitivity, suggesting that extensive vision evaluations are essential for optimal rehabilitation of retinoblastoma survivors.
Article Abstract
Background: Retinoblastoma (RB) and its associated treatments can significantly impact visual acuity. However, little is known regarding other measures of vision, such as contrast sensitivity or saccades. The aim of this study was to describe contrast sensitivity and saccades in children treated for retinoblastoma.
Methods: This cross-sectional study included children aged 5-17 years who had completed treatment for RB. Visual acuity, saccades via fixation analysis, and contrast sensitivity by Cardiff contrast sensitivity were assessed, and multivariable linear regression was performed.
Results: Eleven children were enrolled (mean age, 10.7 ± 3.9 years). Treatment included enucleation (8 children [73%]) and chemotherapy (10 [91%]). Of the 11, one participant was unable to complete testing of saccades, and another was unable to complete contrast sensitivity testing. Decreased saccade parameters (velocity, latency, or accuracy) and impaired contrast sensitivity were observed in all 10 participants who underwent visual testing. Multivariable analysis revealed that worse logMAR visual acuity (B, -4.54 [-6.8, -2.2]; P = 0.004) and bilateral disease (B, -3.9 [-6.4, -1.4]; P = 0.009) were associated with worse contrast sensitivity. Germline disease was associated with decreased vertical saccade accuracy (P = 0.02).
Conclusions: Decreased contrast sensitivity and impaired saccades were universally observed in this cohort of RB survivors. Comprehensive visual evaluation should be considered for all RB survivors to provide optimal rehabilitative services for these patients.
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| http://dx.doi.org/10.1016/j.jaapos.2023.06.003 | DOI Listing |
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