Purpose: Total necrosis of hepatocellular carcinoma (HCC) achieved via locoregional treatment (LRT) is considered to indicate a lack of tumor viability. Nonetheless, there is insufficient evidence of recurrence after liver transplantation (LT) in patients with such a status. The aim of this study was to investigate the prognosis of patients diagnosed with totally necrotic nodules upon explant hepatectomy after LT.
Methods: We conducted a retrospective study of patients diagnosed with totally necrotic nodules after LT for HCC. A total of 165 patients with HCC who underwent living- or deceased-donor LT from 2000 to 2020 in our hospital were included.
Results: A total of 5 patients (3.0%) exhibited HCC recurrence during a median follow-up of 84 months (range, 4-243 months) after LT. The 5-year overall and recurrence-free survival rates of these patients were 92.8% and 92.2%, respectively. Four patients in the HCC-recurrence group (80.0%) died even after further treatment, including transarterial chemoembolization, surgery, and systemic treatment. Both univariate and multivariate analyses of clinicopathological factors identified a maximum diameter of the totally necrotic nodules of >5 cm as the only factor associated with tumor recurrence following LT (P = 0.005 and P = 0.009, respectively).
Conclusion: Total necrosis of HCC via LRT yielded excellent survival outcomes for patients undergoing LT. Nevertheless, patients with large tumors should be considered at high risk of recurrence after LT, suggesting the need for their active surveillance during the follow-up period.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333804 | PMC |
| http://dx.doi.org/10.4174/astr.2023.105.1.47 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The predictive value of monocyte count to high-density lipoprotein cholesterol ratio combined with left atrial diameter for post-radiofrequency ablation recurrence of paroxysmal atrial fibrillation in patients.
J Cardiothorac Surg
December 2024
Department of Cardiovascular Medicine, Deyang People's Hospital, No. 173, Section 1, Taishan North Road, Jingyang District, Deyang, Sichuan Province, 618000, China.
Background: Paroxysmal atrial fibrillation (PAF) usually recurs after radiofrequency ablation (RFA). This study probed the predictive value of monocyte count to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) with left atrial diameter (LAD) for post-RFA recurrence in PFA patients.
Methods: Totally 210 RFA-treated PAF patients were selected and assigned into Recurrence and Non-Recurrence groups, with clinical baseline data recorded.
Acute myocardial infarction presenting as headache: a case report.
J Med Case Rep
December 2024
Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Background: The diagnosis of acute myocardial infarction is straightforward when it presents with typical symptoms. However, some patients can be asymptomatic, and some can present with atypical symptoms.
Case Presentation: We present a very rare case of acute myocardial infraction that presented with headache and right upper limb numbness of 2-day duration in a 61-year-old female Middle Eastern patient.
Long-term follow-up of anti-TNF treatment in adult and pediatric DADA2 patients: Insights from real-world data.
Int J Rheum Dis
November 2024
Vasculitis Research Centre, Hacettepe University, Ankara, Turkey.
Background/purpose: Our objective was to investigate real-world outcomes and treatment strategies in individuals affected by DADA2 using over 10-year period real-life experience.
Methods: This descriptive analysis encompassed all adult/pediatric patients with DADA2 from our Vasculitis Research Center prospective database. Patients on anti-TNF therapy have been specifically examined, analyzing the treatment's duration, indications, and outcomes.
['s subcutaneous needling combined with scalp acupuncture for shoulder-hand syndrome phaseⅠafter cerebral infarction: a randomized controlled trial].
Zhongguo Zhen Jiu
November 2024
Graduate School, Heilongjiang University of CM, Harbin 150001, China; Second Department of Neurorehabilitation, Second Affiliated Hospital of Heilongjiang University of CM, Harbin 150001.
Article Synopsis
- - The study aimed to compare the effects of a combination therapy involving 's subcutaneous needling and scalp acupuncture versus simple scalp acupuncture alone on shoulder-hand syndrome following a stroke.
- - A total of 68 patients were divided into two groups, with both receiving traditional rehab treatments, but one group received additional subcutaneous needling for 14 days.
- - Results showed significant improvements in pain scores, edema, and functional ability for both groups after treatment, with the combination therapy group showing greater benefits than the scalp acupuncture group.
Mechanical Thrombectomy for Treatment of Acute Cerebral Infarction due to Distal Medium Vessel Occlusions: A Retrospective Cohort Study.
Brain Behav
November 2024
Department of Neurology, The Second Hospital of Dalian Medical University, Shahekou District, Liaoning, China.
Background: Mechanical thrombectomy (MT) is standard of care for acute cerebral infarction (ACI) due to large vessel occlusions. However, its clinical efficacy in patients with ACI due to distal medium vessel occlusions (DMVOs) remains unclear. This study evaluates the efficacy and safety of MT in patients with ACI due to DMVOs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!