AI Article Synopsis
- Automated glycan assembly (AGA) allows for the quick production of specific glycans by analyzing how different solid support parameters impact the process.
- The study found that factors like loading and reaction scale had little effect, but the type of linker used significantly affected the yield of the final products.
- Key factors affecting AGA success were identified as the efficiency of cleavage from the solid support and the purification methods used after the assembly process.
Article Abstract
Automated glycan assembly (AGA) affords collections of well-defined glycans in a short amount of time. We systematically analyzed how parameters connected to the solid support affect the AGA outcome for three different glycan sequences. We showed that, while loading and reaction scale did not significantly influence the AGA outcome, the chemical nature of the linker dramatically altered the isolated yields. We identified that the major determinants of AGA yields are cleavage from the solid support and post-AGA purification steps.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334207 | PMC |
| http://dx.doi.org/10.3762/bjoc.19.77 | DOI Listing |
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