Rods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, where proper protein localization and compartmentalization are critical for phototransduction and visual function. In human retinal diseases, improper protein transport to the outer segment (OS) or mislocalization of proteins to the inner segment (IS) could lead to impaired visual responses and photoreceptor cell degeneration, causing a loss of visual function. We showed involvement of an unconventional motor protein, MYO1C, in the proper localization of rhodopsin to the OS, where loss of MYO1C in a mammalian model caused mislocalization of rhodopsin to IS and cell bodies, leading to progressively severe retinal phenotypes. In this study, using modeling and docking analysis, we aimed to identify the protein-protein interaction sites between MYO1C and Rhodopsin to establish a hypothesis that a physical interaction between these proteins is necessary for the proper trafficking of rhodopsin and visual function.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-3-031-27681-1_73 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuropsychological profiles of patients suffering from hallucinogen persisting perception disorder (HPPD): A comparative analysis with psychedelic-using and non-using controls.
Sci Rep
December 2024
Campus Charité Mitte, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Psychiatric University Clinic at Hospital St. Hedwig, 10115, Berlin, Germany.
Classic psychedelics like LSD and psilocybin are showing promising effects in treating certain psychiatric disorders. Despite their low toxicity and lack of an addictive potential, in some individuals, psychedelics can be associated with persisting psychological harms. Hallucinogen Persisting Perception Disorder (HPPD) is one of those complications, a rare disorder characterized by enduring perceptual symptoms without impaired reality control.
View Article and Find Full Text PDFThe Effect of Digital Era on Human Visual Working Memory.
Brain Behav
January 2025
Educational Psychology Division, Public Course Teaching Department, Guangzhou Sport University, Guangzhou, China.
Background: The digital age has had a profound impact on our lives and cognitive abilities, such as working memory. Typically, visual working memory (VWM) is an important aspect of our working memory. As a crucial cognitive function for individuals, VWM has been extensively studied in the context of the digital age and may be affected by the digital age.
View Article and Find Full Text PDFExecutive Function Strengths in Athletes: a Systematic Review and Meta-Analysis.
Brain Behav
January 2025
School of Physical Education, Shanghai University of Sport, Shanghai, China.
Objective: Whether athletes possess superior executive functions still needs further examination. Therefore, the aim of this study is to explore the executive function advantages of athletes and the differences in these advantages between open- and closed-skill sports through systematic review and meta-analysis.
Methods: Computer searches of CNKI, Web of Science, PubMed, ScienceDirect, and SPORTDiscus databases were conducted.
The association between cytokines and cognitive function in patients with major depressive disorder and controls.
J Affect Disord
December 2024
Department of Psychiatry, University of Muenster, Germany; Department of Psychiatry, University of Melbourne, Melbourne, Australia; The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Background: Cognitive dysfunction is a symptom of depression (MDD). While the involvement of the immune system has long been suggested to contribute to the biological underpinnings of depression, less is known about the underpinnings of cognitive dysfunction. A recent genome-wide association study pointed to genes related to immune function to be relevant for cognitive processes in depression.
View Article and Find Full Text PDFImproving functional correlation of quantification of interstitial lung disease by reducing the vendor difference of CT using generative adversarial network (GAN) style conversion.
Eur J Radiol
December 2024
Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Objective: To assess whether CT style conversion between different CT vendors using a routable generative adversarial network (RouteGAN) could minimize variation in ILD quantification, resulting in improved functional correlation of quantitative CT (QCT) measures.
Methods: Patients with idiopathic pulmonary fibrosis (IPF) who underwent unenhanced chest CTs with vendor A and a pulmonary function test (PFT) were retrospectively evaluated. As deep-learning based ILD quantification software was mainly developed using vendor B CT, style-converted images from vendor A to B style were generated using RouteGAN.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!