Optimizing treatments requires the prevention of diagnostic errors. The use of shortcuts, cognitive biases, may lead to errors of judgement that can impair clinical reasoning and distort decision-making. Objective, quantifiable and comparable assessment is a safeguard against this, and for instance force quantification is used for this purpose. We will present here the use of hand-held dynamometers with recommendations for best practice as well as simple but essential tools for interpreting the results. Indeed, the use of these easy-to-use dynamometers requires rigour to ensure the quality of measurements and data analysis by/for the clinician. The use of this equipment should be widely promoted and democratized in informed clinical practice.
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http://dx.doi.org/10.53738/REVMED.2023.19.835.1370 | DOI Listing |
Learn Mem
January 2025
Psychology Department, Hunter College, City University of New York, New York, New York 10065, USA
Social isolation is a risk factor for cognitive impairment. Adolescents may be particularly vulnerable to these effects, because they are in a critical period of development marked by significant physical, hormonal, and social changes. However, it is unclear if the effects of social isolation on learning and memory are similar in both sexes or if they persist into adulthood after a period of recovery.
View Article and Find Full Text PDFLearn Mem
January 2025
Department of Cognitive Neuroscience, Radboud university medical center, 6500 HB Nijmegen, The Netherlands
Stressful and emotionally arousing experiences induce the release of noradrenergic and glucocorticoid hormones that synergistically strengthen memories but differentially regulate qualitative aspects of memory. This highlights the need for sophisticated behavioral tasks that allow for the assessment of memory quality. The dual-event inhibitory avoidance task for rats is such a behavioral task designed to evaluate both the strength and specificity of memory.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
February 2025
Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Neurology
February 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Background And Objectives: Chronic kidney disease (CKD) is known to be associated with increased plasma phosphorylated tau217 (p-tau217) concentrations, potentially confounding the utility of plasma p-tau217 measurements as a marker of amyloid pathology in individuals with suspected Alzheimer disease (AD). In this study, we quantitatively investigate the relationship of plasma p-tau217 concentrations vs estimated glomerular filtration rate (eGFR) in individuals with CKD with and without amyloid pathology.
Methods: This was a retrospective examination of data from 2 observational cohorts from either the Mayo Clinic Study of Aging or the Alzheimer's Disease Research Center cohorts.
Evol Comput
January 2025
University of Jyvaskyla, Faculty of Information Technology, Finland
Interactive methods support decision-makers in finding the most preferred solution for multiobjective optimization problems, where multiple conflicting objective functions must be optimized simultaneously. These methods let a decision-maker provide preference information iteratively during the solution process to find solutions of interest, allowing them to learn about the trade-offs in the problem and the feasibility of the preferences. Several interactive evolutionary multiobjective optimization methods have been proposed in the literature.
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