[Corneal disease in childhood-Hereditary, degenerative or infectious?].

Ophthalmologie

Augenklinik und Poliklinik, Klinikum der Universität München, LMU München, Mathildenstr. 8, 80336, München, Deutschland.

Published: August 2023

AI Article Synopsis

  • - A child's visual acuity is crucial for proper neurobehavioral development, and infantile corneal opacities can lead to a high risk of amblyopia.
  • - This review identifies common causes of infantile corneal opacities, emphasizing the need to rule out metabolic, traumatic, and infectious origins before focusing on corneal dysgenesis, dystrophy, or degeneration.
  • - Early detection and treatment of corneal opacities in children is essential to prevent amblyopia, and histopathological analyses of removed corneas can aid in diagnosing unexplained cases.

Article Abstract

Background: Adequate visual acuity significantly contributes to the age-appropriate development of children's neurobehavior. Infantile corneal opacities are rare but implicate a high potential for amblyopia.

Objective: This review aims to provide an overview of the most common causes of infantile corneal opacities and highlights ophthalmopathological correlations.

Methods: The following review is based on an extensive literature search.

Results: If metabolic diseases, traumatic or infectious events can be excluded as a cause for an infantile corneal opacity, it is important to focus on the 3Ds, corneal dysgenesis, corneal dystrophy or corneal degeneration.

Discussion: If corneal opacities occur in childhood, early recognition, diagnosis, and initiation of treatment, including prophylaxis of amblyopia, are of utmost importance. In unexplained corneal opacities the histopathological work-up of the explanted cornea can contribute to the final diagnosis.

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Source
http://dx.doi.org/10.1007/s00347-023-01897-3DOI Listing

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