AI Article Synopsis
- The J-SIPHE system was utilized to analyze the relationship between antibiotic use and antimicrobial resistance (AMR) at a university hospital from 2013 to 2021.
- Data showed positive correlations between specific antibiotics and resistance rates, revealing that increased use of piperacillin/tazobactam, carbapenems, and quinolones corresponded with higher resistance levels.
- This research emphasizes the value of the J-SIPHE system for enhancing AMR monitoring and prevention strategies within hospital settings.
Article Abstract
Objectives: The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures. We aimed to investigate the correlation between antibiotic use and AMR at a university hospital from 2013 to 2021 in a time series analysis using the J-SIPHE system. We also studied this correlation in each ward (inter-ward analysis).
Methods: Data on antibiotic use and resistance rates were collected from the J-SIPHE system, except for the resistance rate in each ward, which was calculated from the source data prepared for this system.
Results: Piperacillin/tazobactam use was positively correlated with piperacillin/tazobactam resistance in and in the inter-ward analysis, and in in both analyses. Carbapenem use was positively correlated with meropenem resistance in in the time series analysis and in in both analyses, and imipenem/cilastatin resistance in in inter-ward analysis. Quinolone use was positively correlated with levofloxacin resistance in in both analyses, and in in inter-ward analysis.
Conclusions: This is the first study to investigate the correlation between antibiotic use and AMR at a single hospital in time series and inter-ward analyses using the J-SIPHE system and data prepared for this system, suggesting that this system may be useful for promoting AMR measures.
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| http://dx.doi.org/10.1136/ejhpharm-2023-003797 | DOI Listing |
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Article Synopsis
- The J-SIPHE system was utilized to analyze the relationship between antibiotic use and antimicrobial resistance (AMR) at a university hospital from 2013 to 2021.
- Data showed positive correlations between specific antibiotics and resistance rates, revealing that increased use of piperacillin/tazobactam, carbapenems, and quinolones corresponded with higher resistance levels.
- This research emphasizes the value of the J-SIPHE system for enhancing AMR monitoring and prevention strategies within hospital settings.
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J Infect Chemother
January 2023
AMR Clinical Reference Center, National Center for Global Health and Medicine, Tokyo, Japan; Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
The impact of the COVID-19 pandemic on the incidence of microbial infections and other metrics related to antimicrobial resistance (AMR) has not yet been fully described. Using data from Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE), a national surveillance database system that routinely collects clinical and epidemiological data on microbial infections, infection control practices, antimicrobial use, and AMR emergence from participating institutions in Japan, we assessed the temporal changes in AMR-related metrics before and after the start of the COVID-19 pandemic. We found that an apparent decrease in the incidence of microbial infections in 2020 compared with 2019 may have been driven primarily by a reduction in bed occupancy, although the incidence showed a constant or even slightly increasing trend after adjusting for bed occupancy.
View Article and Find Full Text PDFCorrelation between antibiotic use and antibiotic resistance: A multicenter study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system in Hokkaido, Japan.
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Methods: Data on antibiotic use and detection rate of major resistant Gram-negative bacteria at 19 hospitals in 2020 were collected from the J-SIPHE system, and data correlations were analyzed using JMP Pro.
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