AI Article Synopsis
- Radiation-induced lymphopenia (RIL) means that there are fewer lymphocytes, a type of white blood cell, in the blood after someone undergoes radiotherapy for cancer.
- Combining radiotherapy with immunotherapy could help reduce RIL and make treatments work better together, but we don’t fully understand why RIL happens yet.
- This review aims to explain RIL in detail, look at new research about it, and think about new ways to treat patients who are getting both radiotherapy and immunotherapy.
Article Abstract
Radiation-induced lymphopenia (RIL) is characterized by a significant decrease in the absolute number of lymphocytes circulating in the blood after radiotherapy. With the major shift in cancer management initiated by cancer immunotherapy (IT), the reduction of incidence of RIL appears today as an extremely promising way of potentiating the synergy between radiotherapy and immunotherapy. However, the causes of RIL and mechanisms involved are still poorly understood. Improving our knowledge on RIL is therefore essential to limit it and thus improve the quality of care delivered to patients. The objective of this review is to provide a global view of RIL from a clinical point of view, with particular emphasis on recent knowledge and avenues explored to explain RIL and especially its depletion and remission kinetics. An opening on treatment concepts to be rethought is conducted in the context of combined RT/IT treatments.
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| http://dx.doi.org/10.1016/bs.ircmb.2023.03.002 | DOI Listing |
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