Local vibration can induce vascular injuries, one example is the hand-arm vibration syndrome (HAVS) caused by hand-transmitted vibration (HTV). Little is known about the molecular mechanism of HAVS-induced vascular injuries. Herein, the iTRAQ (isobaric tags for relative and absolute quantitation) followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomics approach was applied to conduct the quantitative proteomic analysis of plasma from specimens with HTV exposure or HAVS diagnosis. Overall, 726 proteins were identified in iTRAQ. 37 proteins upregulated and 43 downregulated in HAVS. Moreover, 37 upregulated and 40 downregulated when comparing severe HAVS and mild HAVS. Among them, Vinculin (VCL) was found to be downregulated in the whole process of HAVS. The concentration of vinculin was further verified by ELISA, and the results suggested that the proteomics data was reliable. Bioinformative analyses were used, and those proteins mainly engaged in specific biological processes like binding, focal adhesion, and integrins. The potential of vinculin application in HAVS diagnosis was validated by the receiver operating characteristic curve.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408646 | PMC |
| http://dx.doi.org/10.1021/acs.jproteome.3c00277 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence of Hand Arm Vibration Syndrome in mine workers of Khewra salt mines.
J Hand Ther
January 2025
Neuroscience Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia; King Salman Center for Disability Research, Riyadh, Saudi Arabia.
Background: Hand-arm Vibration Syndrome (HAVS) is a disorder caused by prolonged exposure to hand-held vibrating instruments, commonly observed in industrial contexts such as mining, construction, and manufacturing. It involves symptoms affecting the musculoskeletal, neurological, and vascular systems of the arm and hand.
Purpose: The main aim of this study is to determine the prevalence of HAVS among laborers working in the Khewra salt mines.
Possible differences in the performances of vibration-reducing gloves when used with hammers of different sizes.
Heliyon
November 2024
DIIEM, Department of Industrial, Electronical and Mechanical Engineering, University of Roma Tre, via Vito Volterra, 62, 00146, Rome, Italy.
Protection provided by vibration-reducing gloves (VR) when used with impact tools can be considerably different from that measured following the ISO 10819 Standard. This paper investigates the transmissibility, at the palm level, of three different types of vibration-reducing gloves (air bubbles; gel; neoprene) and a working leather glove, while using 8 different models of electro-pneumatic hammers for chiseling rock in a limestone quarry plant. The capability to reduce the triaxial vibration as the average of all the tested hammers results limited: 12 % for both the gloves in gel and neoprene, and 7 % for the glove in air.
View Article and Find Full Text PDFForce-induced tissue compression alters circulating hormone levels and biomarkers of peripheral vascular and sensorineural dysfunction in an animal model of hand-arm vibration syndrome.
J Toxicol Environ Health A
March 2025
Physical Effects Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Workers regularly using vibrating hand tools may develop a disorder referred to as hand-arm vibration syndrome (HAVS). HAVS is characterized by cold-induced vasospasms in the hands and fingers that result in blanching of the skin, loss of sensory function, pain, and reductions in manual dexterity. Exposure to vibration induces some of these symptoms.
View Article and Find Full Text PDFEvaluation of hand-arm vibration (HAV) exposure among groundskeepers in the southeastern United States.
Ann Work Expo Health
January 2025
Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294-0022, United States.
Objective: The objectives of this study were to evaluate daily hand-arm vibration (HAV) exposure among groundskeepers, characterize power tools used, and estimate lifetime cumulative HAV exposure dose.
Methods: Seventeen groundskeepers and ten office workers employed at two US southeasterrn institutions were recruited as a target exposure group and a reference group, respectively. A 6-d exposure assessment of HAV was scheduled, and vibration dosimeters were used to obtain daily vibration exposure value, A(8).
Case report: Hand-arm vibration syndrome in a dental technician.
Front Public Health
October 2024
Department of Occupational and Environmental Medicine, Singapore General Hospital, Singapore, Singapore.
Article Synopsis
- Occupational exposure to vibration from hand-held tools can lead to hand-arm vibration syndrome (HAVS), as shown in the case of a 39-year-old dental technician who experienced chronic wrist pain, numbness, and tingling for three years after five years of repetitive tool use.
- She was diagnosed with bilateral median nerve neuropathy, mild carpal tunnel syndrome, and had MRI results indicating soft tissue damage due to repetitive strain injury, particularly in her dominant right wrist.
- A workplace health risk assessment identified high-risk tasks associated with her symptoms, leading to modifications and monitoring protocols that helped stabilize her condition.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!