Palladium-Catalyzed Annulative Coupling of Spirovinylcyclopropyl Oxindoles with -Quinone Methides.

Pd-catalyzed annulative coupling of spirovinylcyclopropyl oxindoles with -quinone methides has been accomplished cascade carbon-carbon bond formation to afford -spirooxindole scaffolds. The mild reaction conditions, diastereoselectivity, functional group diversity, post-synthetic transformations, and mechanistic studies using DFT calculations are the important practical features.