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A phase I study of convection-enhanced delivery (CED) of liposomal-irinotecan using real-time magnetic resonance imaging in patients with recurrent high-grade glioma.
J Neurooncol
January 2025
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Background: Irinotecan demonstrates anti-tumor efficacy in preclinical glioma models but clinical results are modest due to drug delivery limitations. Convection enhanced delivery (CED) improves drug delivery by increasing intratumoral drug concentration. Real-time magnetic resonance imaging of infusate delivery during CED may optimize tumor coverage.
View Article and Find Full Text PDFDeveloping an Indocyanine Green Angiography Protocol for Predicting Flap Necrosis During Breast Reconstruction.
Surg Innov
January 2025
Department of Breast Surgery, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.
Background: Although there is evidence that indocyanine green angiography (ICGA) can predict mastectomy skin flap necrosis during breast reconstruction, consensus on optimal protocol is lacking. This study aimed to evaluate various technical factors which can influence ICG fluorescence intensity and thus interpretation of angiograms.
Method: Single institution retrospective study (2015-2021) of immediate implant-based breast reconstructions postmastectomy using a standardized technique of ICGA, controlling for modifiable factors of ambient lighting, camera distance and ICG dose.
Rectal Gas-Induced Dose Changes in Carbon Ion Radiation Therapy for Prostate Cancer: An In Silico Study.
Int J Part Ther
March 2025
Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan.
Purpose: This study aims to determine dosimetric influence of rectal gas in carbon ion radiation therapy (CIRT) for prostate cancer and to establish a procedure for removal rectal gas in clinical scenarios.
Materials And Methods: We analyzed 18 prostate cancer cases with bulky rectal gas. The dose distribution was recalculated on computed tomography (CT) with bulky rectal gas (gasCT) after creating the initial plan on a CT without bulky rectal gas, and the doses were transformed using a displacement vector field.
A Comparative Study of Radiation Dose From Chest CT Scan Examinations in Two Imaging Centers in Duhok Province, Kurdistan, Iraq.
Cureus
December 2024
Radiology, Azadi Teaching Hospital, Duhok, IRQ.
Background CT is among the most widely used diagnostic imaging techniques worldwide, providing significant advantages and invaluable diagnostic insights for detecting a wide range of diseases across various organs. However, it involves exposing patients to relatively high levels of ionizing radiation. Objective This study aims to document the radiation doses from chest CT scans performed at Azadi Teaching Hospital in Duhok Province and compare them with those recorded at the 3-Tesla Center for Advanced MRI and CT Scanning, also located in Duhok, using diagnostic reference levels (DRLs) as a benchmark.
View Article and Find Full Text PDFUltra-low dose rate brachytherapy (uLDR-BT) in treatment of patients with unfavorable intermediate-risk group prostate cancer - retrospective analysis.
Rep Pract Oncol Radiother
December 2024
Brachytherapy Department, Greater Poland Cancer Centre, Poznan, Poland.
Background: Treatment with sole ultra-low dose rate brachytherapy (uLDR-BT) for unfavorable intermediate risk factor (IUR) group prostate cancer patients is not recommended by guidelines due to the lack of strong evidence of its effectiveness. However, there were numerous patients treated with good results with this method in older trials. Purpose of this work was to retrospectively asses effectiveness of uLDR-BT in IUR group treated in our department.
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