To evaluate the prevalence of medications with actionable pharmacogenomic (PGx) safety and efficacy recommendations in patients receiving care from the Veterans Health Administration. Outpatient prescription data from 2011 to 2021 and any documented adverse drug reactions (ADRs) were reviewed for those who received PGx testing at one Veterans Administration location between November 2019 and October 2021. Among the reviewed prescriptions, 381 (32.8%) were associated with an actionable recommendation based on the Clinical Pharmacogenetics Implementation Consortium (CPIC) prescribing guidelines, with 205 (17.7%) for efficacy concerns and 176 (15.2%) for safety concerns. Among those with a documented ADR for a PGx-impacted medication, 39.1% had PGx results that aligned with CPIC recommendations. Medications with actionable PGx recommendations for safety and efficacy concerns are received with similar frequency, and most patients who have undergone PGx testing at the Phoenix Veterans Administration have received medications that may be impacted by PGx testing.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/pgs-2023-0018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Underrepresentation of Hispanic women in science, technology, engineering, mathematics, and medicine.
CA Cancer J Clin
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.
Despite ongoing efforts to increase the number of women in science, technology, engineering, and mathematics (STEM) and in medicine, Hispanic women remain severely underrepresented in these fields. This disparity not only hinders scientific innovation and the delivery of culturally competent medical care but also perpetuates a systemic exclusion. Research specifically addressing the challenges faced by Hispanic women, the extent of underrepresentation in these disciplines, and strategies to mitigate these issues is sparce.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
NIA-Layton Aging & Alzheimer's Disease Research Center, Portland, OR, USA.
Background: Nutrient biomarkers (NBs) may serve as more accurate and precise indicators of dietary intake, particularly in older adults who often have subtle episodic memory recall and digestive/microbiome issues that alter the nutritional substrate readily available to the brain. NBs also allow insight into modes of action and metabolic changes that are actionable targets for modification through nutritional means in hopes of disease prevention and treatment. Prior to broad investment and deployment, the pre-analytical and intra-individual temporal variation over time should be documented to design and interpret clinical and epidemiological studies properly.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Department of Neurology, Columbia University, New York, NY, USA.
Background: Structural determinants of health may be important drivers of late-life cognitive decline and dementia risk for women who have a disproportionate burden of Alzheimer's disease (AD). This study examines how early life exposure to structural sexism influences cognitive trajectories among women racialized as Black and White.
Method: This study analyzed longitudinal data from two cohort studies: the Washington Heights-Inwood Columbia Aging Project (WHICAP) and the Health and Retirement Study (HRS).
The global prevalence of dementia is on a concerning rise, currently affecting 55 million people. It is projected to triple in the next 30 years, leading to a profound impact on the quality of life (QoL) for both people living with dementia (PLWDs) and care partners (CPs). The compounded challenges, encompassing mental, physical, and financial aspects, significantly affect the QoL of PLWDs and CPs, creating an urgent need for comprehensive understanding and tailored interventions.
View Article and Find Full Text PDFWill more veterinarians lead to more pet owners going to the veterinarian?
Can Vet J
January 2025
Darren Osborne has been the Director of Economic Research for the Ontario Veterinary Medical Association for over 20 years. He completed an MA (Economics) from York University and has worked as an economic analyst in veterinary medicine, dentistry, human medicine, and the transport industry.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!