AI Article Synopsis
- Patients who were in the ICU due to SARS-CoV-2 can experience muscle weakness for over a year after being discharged, with females showing more impairment than males.
- A study assessed physical functioning in groups of male and female patients at two different time points (3-6 months and 6-12 months post-discharge) and measured factors like fatigue, strength, and neural drive.
- Results indicated no significant sex differences in the early follow-up, but by 6-12 months, females had noticeably greater impairments in strength and overall physical functioning, highlighting the need to consider sex in post-COVID rehabilitation efforts.
Article Abstract
Introduction: Patients admitted to the intensive care unit (ICU) following severe acute respiratory syndrome 2 (SARS-CoV-2) infection may have muscle weakness up to 1 year or more following ICU discharge. However, females show greater muscle weakness than males, indicating greater neuromuscular impairment. The objective of this work was to assess sex differences in longitudinal physical functioning following ICU discharge for SARS-CoV-2 infection.
Methods: We performed longitudinal assessment of physical functioning in two groups: 14 participants (7 males, 7 females) in the 3-to-6 month and 28 participants (14 males, 14 females) in the 6-to-12 month group following ICU discharge and assessed differences between the sexes. We examined self-reported fatigue, physical functioning, compound muscle action potential (CMAP) amplitude, maximal strength, and the neural drive to the tibialis anterior muscle.
Results: We found no sex differences in the assessed parameters in the 3-to-6-month follow-up, indicating significant weakness in both sexes.Sex differences emerged in the 6-to-12-month follow-up. Specifically, females exhibited greater impairments in physical functioning, including lower strength, walking lower distances, and high neural input even 1 year following ICU-discharge.
Discussion: Females infected by SARS-CoV-2 display significant impairments in functional recovery up to 1 year following ICU discharge. The effects of sex should be considered in post-COVID neurorehabilitation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330713 | PMC |
| http://dx.doi.org/10.3389/fmed.2023.1185479 | DOI Listing |
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