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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331771 | PMC |
| http://dx.doi.org/10.21037/jgo-22-998 | DOI Listing |
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Human epidermal growth factor receptor 2 (HER2, also known as ERBB2) signaling promotes cell growth and differentiation, and is overexpressed in several tumor types, including breast, gastric and colorectal cancer. HER2-targeted therapies have shown clinical activity against these tumor types, resulting in regulatory approvals. However, the efficacy of HER2 therapies in tumors with HER2 mutations has not been widely investigated.
View Article and Find Full Text PDFLater lines of systemic therapy in patients with metastatic colorectal cancer: real-world data from a setting with barriers to access cancer therapies.
J Gastrointest Oncol
December 2024
Division of Gastrointestinal Medical Oncology, Oncoclinicas, São Paulo, Brazil.
Background: Regorafenib and trifluridine/tipiracil (TFD/TPI) are oral systemic therapies with survival benefit in chemorefractory metastatic colorectal cancer (mCRC) patients, but they are not widely available worldwide. We aimed to evaluate the treatment patterns and outcomes of patients with limited access to these drugs.
Methods: Retrospective study involving 510 patients with mCRC who were treated at five different centers in Brazil, from January 2011 to December 2019.
Closing the Gap: Approaches to Improving Colorectal Surgery Care for the Uninsured and Underinsured.
Clin Colon Rectal Surg
January 2025
Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan.
Health insurance plays a critical role in access to and delivery of health care in the United States. As the only industrialized nation without universal health coverage, Americans without adequate insurance (i.e.
View Article and Find Full Text PDFInternational Planetary Health Education in Undergraduate and Graduate Medical Curricula: A Scoping Review.
J Grad Med Educ
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is Colorectal Surgeon, Professor of Surgery, and Director of Planetary Health, Department of Surgery, The Ottawa Hospital, School of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Climate change is a public health emergency, yet planetary health education is absent for many medical and health professions trainees. To perform a scoping review exploring the inclusion of planetary health in undergraduate and graduate medical education. A search strategy was developed with a health sciences librarian and run on 6 databases from their inception to February 2022: MEDLINE, Embase, APA PsycInfo, CINAHL, Global Health, and Scopus.
View Article and Find Full Text PDFGynecologic cancer screening among women with Lynch syndrome: Information and healthcare access needs.
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Zane Cohen Centre for Digestive Diseases, Sinai Health System, Toronto, Canada; Department of Psychology, Toronto Metropolitan University, Toronto, Canada. Electronic address:
Objectives: Screening recommendations for gynecologic cancers (GC) associated with Lynch syndrome (LS) are diverse. The objectives of this study were to examine among women with LS: 1) psychosocial factors that influence thoughts and choices about GC screening, and 2) information and unmet healthcare access needs when making GC screening decisions.
Methods: This study used a qualitative design.
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