AI Article Synopsis
- The study focused on detecting myelin oligodendrocyte glycoprotein autoantibodies (MOG-Ab), crucial for diagnosing MOG-Ab-associated disease (MOGAD), and explored the clinical implications of different recognized epitopes.
- Researchers created a cell-based immunoassay to identify MOG-Ab epitopes and conducted a retrospective review of 55 patients in a registry, evaluating their serum samples.
- Key findings revealed that the P42 epitope in MOG is a significant target for MOG-Ab, primarily associated with monophasic disease and childhood onset in affected patients, highlighting the need for further research on MOG-Ab's predictive value and epitopes.
Article Abstract
Background: The detection of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Ab) is essential for the diagnosis of MOG-Ab-associated disease (MOGAD). The clinical implications of different epitopes recognized by MOG-Ab are largely unknown. In this study, we established an in-house cell-based immunoassay for detecting MOG-Ab epitopes and examined the clinical characteristics of patients with MOG-Ab according to their epitopes.
Methods: We conducted a retrospective review of patients with MOG-Ab-associated disease (MOGAD) in our single center registry, and collected serum samples from enrolled patients. Human MOG variants were generated to detect epitopes recognized by MOG-Ab. The differences in clinical characteristics according to the presence of reactivity to MOG Proline42 (P42) were evaluated.
Results: Fifty five patients with MOGAD were enrolled. Optic neuritis was the most common presenting syndrome. The P42 position of MOG was a major epitope of MOG-Ab. The patients with a monophasic clinical course and childhood-onset patients were only observed in the group that showed reactivity to the P42 epitope.
Conclusion: We developed an in-house cell-based immunoassay to analyze the epitopes of MOG-Ab. The P42 position of MOG is the primary target of MOG-Ab in Korean patients with MOGAD. Further studies are needed to determine the predictive value of MOG-Ab and its epitopes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331291 | PMC |
| http://dx.doi.org/10.3389/fneur.2023.1200961 | DOI Listing |
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