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Highly Relapsing Anti-GABAA Receptor Encephalitis: A Case with Four Immunotherapy-Responsive Episodes.
Neurol India
November 2024
Department of Neurology, Neuroimmunology Laboratory, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux.
Front Pharmacol
October 2024
Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Saint Joseph's University, Pharmacology and Toxicology Center, Philadelphia, PA, United States.
Triple negative breast cancer (TNBC) is known for its heterogeneous nature and aggressive onset, limited unresponsiveness to hormone therapies and immunotherapy as well as high likelihood of metastasis and recurrence. Since no targeted standard treatment options are available for TNBC, novel and effective therapeutic targets are urgently needed. Ion channels have emerged as possible novel therapeutic candidates for cancer therapy.
View Article and Find Full Text PDFChronic ethanol exposure in mice evokes pre- and postsynaptic deficits in GABAergic transmission in ventral tegmental area GABA neurons.
Br J Pharmacol
January 2025
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
Background And Purpose: GABAergic neurons in mouse ventral tegmental area (VTA) exhibit elevated activity during withdrawal following chronic ethanol exposure. While increased glutamatergic input and decreased GABA receptor sensitivity have been implicated, the impact of inhibitory signaling in VTA GABA neurons has not been fully addressed.
Experimental Approach: We used electrophysiological and ultrastructural approaches to assess the impact of chronic intermittent ethanol vapour exposure in mice on GABAergic transmission in VTA GABA neurons during withdrawal.
MRI findings in autoimmune encephalitis.
Rev Neurol (Paris)
November 2024
Charité - Universitätsmedizin Berlin, Department of Neurology and Experimental Neurology, Berlin, Germany; Humboldt-Universität zu Berlin, Berlin School of Mind and Brain, Berlin, Germany; Charité - Universitätsmedizin Berlin, Einstein Center for Neurosciences Berlin, Berlin, Germany. Electronic address:
Article Synopsis
- In NMDA receptor encephalitis, most patients have normal MRIs during acute episodes, but subtle lesions can occur; these lesions may signal overlaps with conditions like multiple sclerosis or neuromyelitis optica.
- Other types, such as limbic encephalitis related to LGI1, CASPR2, and GAD antibodies, show specific hyperintensities in the medial temporal lobe on MRI, while GABA receptor encephalitides present different patterns of lesions, underscoring the importance of MRI in diagnosing autoimmune encephalitis and differentiating it from other disorders.
Role of dorsal striatum circuits in relapse to opioid seeking after voluntary abstinence.
Neuropsychopharmacology
December 2024
Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD, USA.
High relapse rate during abstinence is a defining characteristic of drug addiction. We previously found that opioid seeking progressively increases after voluntary abstinence induced by adverse consequences of oxycodone seeking (crossing an electric barrier). Functional MRI revealed that this effect is associated with changes in functional connectivity within medial orbitofrontal cortex (mOFC)- and dorsomedial striatum (DMS)-related circuits.
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