Recent electron microscopy-based connectomes of the Caenorhabditis elegans nervous system provide a new opportunity to test classic models for the development of brain wiring. Statistical analyses now reveal that neuronal adjacencies (the contactome) can partly predict synaptic connectivity (the connectome).
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Premature birth changes wiring constraints in neonatal structural brain networks.
Nat Commun
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MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Structural brain organization in infancy is associated with later cognitive, behavioral, and educational outcomes. Due to practical limitations, such as technological advancements and data availability of fetal MRI, there is still much we do not know about the early emergence of topological organization. We combine the developing Human Connectome Project's large infant dataset with generative network modeling to simulate the emergence of network organization over early development.
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Sorbonne Université, INSERM, CNRS, Institut de la Vision, F-75012 Paris, France.
Signal transduction downstream of axon guidance molecules is essential to steer developing axons. Second messengers including cAMP are key molecules shared by a multitude of signaling pathways and are required for a wide range of cellular processes including axon pathfinding. Yet, how these signaling molecules achieve specificity for each of their downstream pathways remains elusive.
View Article and Find Full Text PDFThe connectome describes the complete set of synaptic contacts through which neurons communicate. While the architecture of the $\textit{C. elegans}$ connectome has been extensively characterized, much less is known about the organization of causal signaling networks arising from functional interactions between neurons.
View Article and Find Full Text PDFDisentangling how the brain is wired.
Fly (Austin)
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Patterns of the left thalamus embedding into the connectome associated with reading skills in children with reading disabilities.
Netw Neurosci
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Department of Psychology, The University of Western Ontario, London, Canada.
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