AI Article Synopsis
- Migraine affects about 14% of the population and is a leading cause of disability, particularly among young women, yet it remains underdiagnosed and undertreated.
- Research suggests that microRNAs, small non-coding molecules, may play a significant role in the diagnosis and treatment of migraine, as studies indicate their potential as promising biomarkers and their influence on neuroinflammation related to migraine.
- A systematic review of 21 studies was conducted to explore the role of microRNAs in migraines, emphasizing the need for further research in this area.
Article Abstract
Migraine is a common primary headache disorder, affecting about 14% of the population. Importantly, it was indicated as the second cause of disability globally and the leading cause among young women. Despite the widespread prevalence, migraine remains underdiagnosed and undertreated. The possible solution may be microRNAs-small, non-coding molecules. Until now, multiple studies have shown the great value of microRNA in both the diagnosis and treatment of different human diseases. Furthermore, a significant role in neurological disorders has been suggested. Little research regarding the utility of microRNA in migraine has been conducted, however, the results so far appear to be promising. We performed an electronic article search through PubMed and Embase Database to further explore the topic. After the analysis, according to PRISMA 2020 guidelines, we included 21 studies. The dysregulation was observed in migraine in general, as well as in different types and phases; thus, miRNAs emerge as promising diagnostic biomarkers. Additionally, some studies showed the influence of the intervention with miRNA levels on neuroinflammation and the expression of peptides, which are crucial in migraine pathogenesis. This review aims to summarize the current knowledge about the role of miRNAs in migraine and encourage to further research in this field.Kindly check and confirm the edit made in the title.I checked and confirm.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477106 | PMC |
| http://dx.doi.org/10.1007/s10571-023-01387-9 | DOI Listing |
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