AI Article Synopsis
- Akkermansia muciniphila is gaining attention as a next-generation probiotic due to its positive effects on gut health and host physiology.
- Its abundance in the gut is influenced by genetic and dietary factors, impacting microbiota behaviors and balance between dysbiosis and eubiosis.
- There are still challenges to overcome, such as regulatory issues, the need for clinical trials, and sustainable manufacturing before it can be widely used as a probiotic.
Article Abstract
Due to its physiological benefits from in vitro and in vivo points of view, Akkermansia muciniphila, a common colonizer in the human gut mucous layer, has consistently been identified as an option for the next-generation probiotic. A. muciniphila is a significant bacterium that promotes host physiology. However, it also has a great deal of potential to become a probiotic due to its physiological advantages in a variety of therapeutic circumstances. Therefore, it can be established that the abundance of A. muciniphila in the gut environment, which is controlled by many genetic and dietary variables, is related to the biological behaviors of the intestinal microbiota and gut dysbiosis/eubiosis circumstances. Before A. muciniphila is widely utilized as a next-generation probiotic, regulatory obstacles, the necessity for significant clinical trials, and the sustainability of manufacturing must be eliminated. In this review, the outcomes of recent experimental and clinical reports are comprehensively reviewed, and common colonization patterns, main factors involved in the colonization of A. muciniphila in the gut milieu, their functional mechanisms in establishing homeostasis in the metabolic and energy pathways, the promising delivery role of microencapsulation, potential genetic engineering strategies, and eventually safety issues of A. muciniphila have been discussed.
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| http://dx.doi.org/10.1007/s12602-023-10118-x | DOI Listing |
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