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| http://dx.doi.org/10.1093/schbul/sbad104 | DOI Listing |
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Potential role of formononetin as a novel natural agent in Alzheimer's disease and osteoporosis comorbidity.
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Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
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Beijing Huilongguan Hospital, Peking University Huilongguan School of Clinical Medicine, Beijing 100096, China.
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Background: Cardiac autonomic dysfunction (CADF) is a major contributor to increased cardiac mortality in schizophrenia patients. The aberrant function of voltage-gated ion channels, which are widely distributed in the brain and heart, may link schizophrenia and CADF. In search of channel-encoding genes that are associated with both CADF and schizophrenia, and are promising candidates.
View Article and Find Full Text PDFIncreased Ca1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly.
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Department of Cardiovascular Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, 520-2192, Japan.
Timothy syndrome (TS) is a rare pleiotropic disorder associated with long QT syndrome, syndactyly, dysmorphic features, and neurological symptoms. Several variants in exon 8 or 8a of CACNA1C, a gene encoding the α-subunit of voltage-gated Ca channels (Ca1.2), are known to cause classical TS.
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