In recent decades, evidence-based medicine acquired special importance in medicine. Therefore, proper presentation of data obtained in scientific research is extremely important. The statistical data processing, being an integral part of this process, often causes difficulties for researchers and its incorrect application results in distortion of results obtained. The purpose of the study is to comparatively analyze programs and methods of statistical data processing applied in dissertations on obstetrics and gynecology in 2011-2021, to examine trends in choosing them depending on specificity of research issue and to identify shortcomings erred by authors in choosing or describing data processing methods. The sampling for analysis included 258 abstracts of candidate's dissertations in the specialty "obstetrics and gynecology", defended in 2011-2021. The analysis covered the programs and methods of mathematical data processing. Over the past decade, significant complication of statistical processing of results of clinical trials in obstetrics and gynecology occurred in part of methods applied. The application of binary logistic regression and discriminant analysis increased most significantly over the past decade. Such sophisticated methods of statistical data processing as factor analysis, decision trees, ordinal logistic regression and neural networks began to be used too. The trend of gradual replacement of parametric methods (Student's t-test, one-way analysis of variance) by such corresponding non-parametric methods as Mann-Whitney test, Kruskal-Wallis test. The Microsoft Excel and Statistica were used most often for data processing. In recent years, the software SPSS Statistics is actively applied. However, problems in describing statistical methods used in dissertations continue to be present. In significant part of dissertations information about statistical program applied, methods of assessing of quantitative data distribution and criteria of significance of obtained results is absent. The proper application of statistical programs, methods of information processing, adequate interpretation of results as well as provision of complete information about methodological support are the key points to carry out modern research resulting in trusted attitude to scientific work and its results.
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http://dx.doi.org/10.32687/0869-866X-2023-31-3-448-452 | DOI Listing |
Indian J Gastroenterol
January 2025
Department of Gastroenterology, Christian Medical College, Vellore, 632 517, India.
Background: Groove pancreatitis (GP) is a form of pancreatitis that affects the pancreaticoduodenal groove area, which lies between the head of the pancreas, the second part of the duodenum and the distal bile duct, presenting as abdominal pain and gastric outlet obstruction. In this study, we present the clinical and radiological characteristics of individuals diagnosed with groove pancreatitis at our center and discuss the use of a conservative treatment approach in managing GP.
Methods: The data of patients with groove pancreatitis treated at our center between January 2012 and December 2021 was analyzed.
Drugs
January 2025
Lysosomal Storage Disorders Unit, Royal Free London NHS Foundation Trust, University College London, London, NW3 2QG, UK.
Lysosomal storage disorders (LSDs) are rare inherited metabolic disorders characterized by defects in the function of specific enzymes responsible for breaking down substrates within cellular organelles (lysosomes) essential for the processing of macromolecules. Undigested substrate accumulates within lysosomes, leading to cellular dysfunction, tissue damage, and clinical manifestations. Clinical features vary depending on the degree and type of enzyme deficiency, the type and extent of substrate accumulated, and the tissues affected.
View Article and Find Full Text PDFDig Dis Sci
January 2025
Ningxia Medical University, Xing Qing Block, Shengli Street No.1160, Yin Chuan City, 750004, Ningxia Province, People's Republic of China.
Background: Colon adenocarcinoma (COAD) is a leading cause of cancer-related mortality worldwide. Transient receptor potential vanilloid 4 (TRPV4), a calcium-permeable non-selective cation channel, has been implicated in various cancers, including COAD. This study investigates the role of TRPV4 in colon adenocarcinoma and elucidates its potential mechanism via the ferroptosis pathway.
View Article and Find Full Text PDFDrugs Aging
January 2025
Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
View Article and Find Full Text PDFJ Community Genet
January 2025
Graduate Program in Structural and Functional Biology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
In 2018, Portuguese researchers proposed the "Tool for Quality Assessment of Genetic Counseling," a 5-point Likert scale comprising 50 items across five dimensions, designed to assess genetic counseling from the professional's perspective. This descriptive, cross-sectional study aimed to adapt this tool to Brazilian Portuguese, validate it among Brazilian clinical geneticists, and conduct a preliminary assessment of the quality of genetic counseling in Brazil. The adaptation process involved expert-driven content validation and calculation of the Content Validity Index (CVI) to ensure equivalence between the original and adapted versions.
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