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Blood-Based Biomarkers in Frontotemporal Dementia: A Narrative Review.
Int J Mol Sci
November 2024
Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, 41100 Larissa, Greece.
This narrative review explores the current landscape of blood biomarkers in Frontotemporal dementia (FTD). Neurofilament light chain (NfL) may be useful in the differentiation of behavioral variant FTD from primary psychiatric disorders (PPDs) or dementia with Lewy bodies (DLB). In prodromal FTD and presymptomatic mutation carriers (, , ), elevated NfL may herald pheno-conversion to full-blown dementia.
View Article and Find Full Text PDFClinical effects of CYP2D6 phenoconversion in patients with psychosis.
J Psychopharmacol
December 2024
Outpatient Clinic Pharmacogenetics, Parnassia Groep, Amsterdam, The Netherlands.
Background: Pharmacogenetics is considered a promising avenue for improving treatment outcomes, yet evidence arguing for the use of pharmacogenetics in the treatment of psychotic disorders is mixed and clinical usefulness is under debate. Many patients with psychosis use multiple medications, which can alter the metabolic capacity of enzymes, a process called phenoconversion. In clinical studies, treatment outcomes of drugs for psychosis management may have been influenced by phenoconversion.
View Article and Find Full Text PDFPlasma level of alpha-synuclein oligomers as a biomarker for isolated rapid eye movement sleep behavior disorder diagnosis and progression: a prospective cohort study.
Front Neurol
August 2024
Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background: Alpha-synuclein oligomers (o-α-syn) are pivotal in the pathogenesis of α-synucleinopathy. Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) serves as an early indicator of the disease, offering insights into disease mechanisms and early intervention. Nevertheless, the diagnostic and predictive potential of o-α-syn in iRBD remains largely unexplored.
View Article and Find Full Text PDFOvarian Cancer Cell-Conditioning Medium Induces Cancer-Associated Fibroblast Phenoconversion through Glucose-Dependent Inhibition of Autophagy.
Int J Mol Sci
May 2024
Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.
One aspect of ovarian tumorigenesis which is still poorly understood is the tumor-stroma interaction, which plays a major role in chemoresistance and tumor progression. Cancer-associated fibroblasts (CAFs), the most abundant stromal cell type in the tumor microenvironment, influence tumor growth, metabolism, metastasis, and response to therapy, making them attractive targets for anti-cancer treatment. Unraveling the mechanisms involved in CAFs activation and maintenance is therefore crucial for the improvement of therapy efficacy.
View Article and Find Full Text PDFAn update on multiple system atrophy.
Curr Opin Neurol
August 2024
Dysautonomia Center, NYU Langone Health, NYU Grossman School of Medicine, New York, New York, USA.
Article Synopsis
- Multiple system atrophy (MSA) is a serious neurological disorder marked by symptoms like autonomic failure, parkinsonism, and problems with coordination, primarily linked to α-synuclein protein issues.
- Recent research suggests urinary infections may trigger α-synuclein aggregation, and updated diagnostic criteria improve early detection accuracy of the disease.
- New diagnostic tools, including α-synuclein biomarkers from urine and brain scans, are being developed alongside clinical trials for various therapies aimed at slowing or reversing the disease's progression.
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