AI Article Synopsis
- Studying HIV transmission in infants helps us understand how antibodies passed from mothers can affect HIV outcomes and disease progression.
- Research using specialized tests showed that infants who developed antibodies to a specific part of the HIV virus (C5) had better survival rates in two different groups.
- The findings indicate that having these specific antibodies may improve survival and slow down the virus's impact, highlighting the need for further research on their protective effects.
Article Abstract
Studying vertical human immunodeficiency virus (HIV) transmission enables the impact of passively transferred antibodies on HIV transmission and pathogenesis to be examined. Using phage display of HIV envelope peptides and peptide enzyme-linked immunosorbent assay (ELISA), we found that, in infants who acquired HIV, passive antibody responses to constant region 5 (C5) were associated with improved survival in 2 cohorts. In a combined analysis, C5 peptide ELISA activity was correlated directly with survival and estimated infection time and inversely with set point viral load. These results suggest that preexisting C5-specific antibodies may be correlated with the survival of infants living with HIV, motivating additional research into their protective potential.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323728 | PMC |
| http://dx.doi.org/10.1093/ofid/ofad316 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!