Introduction: Charles Bonnet Syndrome (CBS) refers to visual hallucinations in visually impaired patients without psychiatric illness who are typically aware that their hallucinations are not real. Rare cases in the literature describe patients with atypical CBS, or CBS plus, who experience hallucinations in the context of sensory deficits but do not meet all of the criteria of a CBS diagnosis. These cases may include hallucinations in more than one sensory modality, including auditory hallucinations, which are thought to arise by a similar pathophysiology to that of the visual hallucinations in CBS. Unfortunately, the clinical criteria for atypical CBS are ambiguous, potentially explaining the rarity of the diagnosis. In addition, certain features of atypical CBS may make the condition particularly prone to misdiagnosis.

Case Presentation: We report a case of atypical CBS in a 67-year-old white male patient presenting with visual and auditory hallucinations that were improved by reassurance. Alongside this case presentation, we provide a review of atypical CBS cases in the literature to compare the diverse features of the syndrome. For this review, we included cases of atypical CBS or CBS plus within the past 20 years for which we could obtain the full text.

Conclusion: Clearer guidelines for the diagnosis of atypical CBS and greater attention to the disorder could substantially improve the management of patients presenting with hallucinations. A broader differential diagnosis including atypical CBS for elderly patients with new-onset hallucinations could help clinicians and patients avoid unnecessary medical workup and treatment.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324678PMC
http://dx.doi.org/10.36518/2689-0216.1303DOI Listing

Publication Analysis

Top Keywords

atypical cbs
32
cbs
13
hallucinations
9
charles bonnet
8
bonnet syndrome
8
visual hallucinations
8
cases literature
8
atypical
8
cbs cbs
8
auditory hallucinations
8

Similar Publications

Article Synopsis
  • A multicenter study in Japan began in 2014 to gather data on progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) to better understand their clinical features and identify potential biomarkers.
  • Initial assessments of 349 patients focused on symptoms, clinical scores (like the PSPRS), and factors affecting disease progression over eight years.
  • Results indicated that patients with Richardson's syndrome (RS) had better clinical scores compared to those with CBD, and cognitive dysfunction played a significant role in disease severity and progression.
View Article and Find Full Text PDF
Article Synopsis
  • Fungal food products, particularly from the strain Rhizomucor pusillus CBS 143028, are seen as sustainable and nutritious options for consumers, with the potential to enhance food supply sustainability.
  • The fermentation of R. pusillus CBS 143028 produces a mycelium biomass rich in proteins, micronutrients, and cell wall components, but it is classified as a novel food which necessitates a safety assessment.
  • A 90-day toxicity study on Wistar rats showed no biologically relevant adverse effects from high doses of R. pusillus mycelium, leading to a no-observed-adverse-effect level (NOAEL) established at 300,000 ppm.
View Article and Find Full Text PDF

Introduction: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are tauopathic atypical parkinsonisms. Given their overlap in terms of clinical manifestation, there is growing interest in the mechanisms leading to these entities.

Materials And Methods: In total, 71 patients were included in the study, 19 of whom were clinically diagnosed with CBS, 37 with PSP, and 15 with Parkinson's disease (PD).

View Article and Find Full Text PDF

Atypical parkinsonian syndromes (APSs) are a group of neurodegenerative disorders that differ from idiopathic Parkinson's disease (IPD) in their clinical presentation, underlying pathology, and response to treatment. APSs include conditions such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and dementia with Lewy bodies (DLB). These disorders are characterized by a combination of parkinsonian features and additional symptoms, such as autonomic dysfunction, supranuclear gaze palsy, and asymmetric motor symptoms.

View Article and Find Full Text PDF

Introduction: Corticobasal syndrome (CBS) is a rare form of atypical parkinsonism, most commonly caused by neurodegenerative disorders. Autoimmune underlying conditions are extremely rare, and anti-Yo antibody-associated CBS has not been reported yet.

Case Report: Herein, we describe a case of a 68-year-old woman presenting with progressive dysarthria, gait instability and difficulty using her left hand with subacute deterioration during the last 3 months.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!