Introduction: Charles Bonnet Syndrome (CBS) refers to visual hallucinations in visually impaired patients without psychiatric illness who are typically aware that their hallucinations are not real. Rare cases in the literature describe patients with atypical CBS, or CBS plus, who experience hallucinations in the context of sensory deficits but do not meet all of the criteria of a CBS diagnosis. These cases may include hallucinations in more than one sensory modality, including auditory hallucinations, which are thought to arise by a similar pathophysiology to that of the visual hallucinations in CBS. Unfortunately, the clinical criteria for atypical CBS are ambiguous, potentially explaining the rarity of the diagnosis. In addition, certain features of atypical CBS may make the condition particularly prone to misdiagnosis.
Case Presentation: We report a case of atypical CBS in a 67-year-old white male patient presenting with visual and auditory hallucinations that were improved by reassurance. Alongside this case presentation, we provide a review of atypical CBS cases in the literature to compare the diverse features of the syndrome. For this review, we included cases of atypical CBS or CBS plus within the past 20 years for which we could obtain the full text.
Conclusion: Clearer guidelines for the diagnosis of atypical CBS and greater attention to the disorder could substantially improve the management of patients presenting with hallucinations. A broader differential diagnosis including atypical CBS for elderly patients with new-onset hallucinations could help clinicians and patients avoid unnecessary medical workup and treatment.
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http://dx.doi.org/10.36518/2689-0216.1303 | DOI Listing |
Clin Park Relat Disord
October 2024
Department of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuoku, Niigata 951-8585, Japan.
J Appl Toxicol
October 2024
Charles River Laboratories Hungary Kft., Veszprém, Hungary.
Front Neurol
October 2024
Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
Introduction: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are tauopathic atypical parkinsonisms. Given their overlap in terms of clinical manifestation, there is growing interest in the mechanisms leading to these entities.
Materials And Methods: In total, 71 patients were included in the study, 19 of whom were clinically diagnosed with CBS, 37 with PSP, and 15 with Parkinson's disease (PD).
J Clin Med
September 2024
Department of Neurology, Medical University of Warsaw, 03-242 Warsaw, Poland.
Atypical parkinsonian syndromes (APSs) are a group of neurodegenerative disorders that differ from idiopathic Parkinson's disease (IPD) in their clinical presentation, underlying pathology, and response to treatment. APSs include conditions such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and dementia with Lewy bodies (DLB). These disorders are characterized by a combination of parkinsonian features and additional symptoms, such as autonomic dysfunction, supranuclear gaze palsy, and asymmetric motor symptoms.
View Article and Find Full Text PDFCurr Med Res Opin
October 2024
1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Corticobasal syndrome (CBS) is a rare form of atypical parkinsonism, most commonly caused by neurodegenerative disorders. Autoimmune underlying conditions are extremely rare, and anti-Yo antibody-associated CBS has not been reported yet.
Case Report: Herein, we describe a case of a 68-year-old woman presenting with progressive dysarthria, gait instability and difficulty using her left hand with subacute deterioration during the last 3 months.
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