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| http://dx.doi.org/10.1016/j.xjon.2023.04.003 | DOI Listing |
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Interplay between elevated RAB5B gene expression and insulin resistance among women with PCOS-insights from a case-control study.
Endocrine
December 2024
Department of Endocrinology, Sher-i- Kashmir Institute of Medical Sciences, Srinagar, India.
Background: Polycystic ovary syndrome (PCOS) represents a multifaceted endocrine, reproductive, and metabolic disorder characterized by hyperandrogenism and hyperinsulinemia-induced insulin resistance (IR). Recent studies reported that the etiology of PCOS is likely correlated with genes involved in steriodogenesis, IR and glucose metabolism. Among the candidate genes in insulin signaling pathways, RAB5B, a small GTPase involved in vesicle trafficking, significantly impacts cellular pathways in ovarian follicular cells, leading to clinical and endocrine changes among women with PCOS.
View Article and Find Full Text PDFIntroduction: Latina, Latino, Latinx, Latine, Hispanic, or of Spanish origin+ (LHS+) women face higher cervical cancer risks, incidence, and mortality compared to non-Hispanic White women. These disparities are attributable to socioeconomic factors, limited access to health care, language and cultural barriers, and negative health care experiences.
Methods: We used the Kern model to design, implement, and evaluate a workshop to educate medical students and health care professionals on cervical cancer disparities among LHS+ women and culturally competent communication skills.
Interactions of spontaneous abortion with gene and dietary carotenoids; a case-control study.
J Nutr Sci
December 2024
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Spontaneous abortion (SA) is a common complication in pregnancy influenced by genetic factors and maternal nutrition.
- A study analyzed 192 women with a history of SA versus 347 healthy women, examining the impact of dietary carotenoids and specific gene polymorphisms on the occurrence of SA.
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Association of HPA Antigens with Immune Thrombocytopenia: A Case-Control Study by PCR-SSP Method.
Int J Hematol Oncol Stem Cell Res
October 2024
Department of Immunology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Human platelet antigens (HPAs) play a clinically significant role in alloimmunization and the development of immune-mediated disorders such as immune thrombocytopenia (ITP), fetal and neonatal alloimmune thrombocytopenia (FNAIT), and post-transfusion purpura (PTP). Understanding the genetic profiles of HPAs is critical for preventing and treating these conditions. Given the limitations of serological methods in determining HPA genotypes, this study aims to investigate the association between the genotypes of HPA1, HPA2, HPA3, HPA4, and HPA15 antigens and autoimmune thrombocytopenia in Lorestan Province, utilizing the PCR-SSP method.
View Article and Find Full Text PDFRepresenting DNA for machine learning algorithms: A primer on one-hot, binary, and integer encodings.
Biochem Mol Biol Educ
December 2024
Department of Biology, Faculty of Science, Naresuan University, Phitsanulok, Thailand.
This short paper presents an educational approach to teaching three popular methods for encoding DNA sequences: one-hot encoding, binary encoding, and integer encoding. Aimed at bioinformatics and computational biology students, our learning intervention focuses on developing practical skills in implementing these essential techniques for efficient representation and analysis of genetic data. The primary goal of this study is to enhance students' understanding and practical application of DNA encoding methods, which are crucial for various computational analyses in bioinformatics.
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