AI Article Synopsis
- Surgical site infections, particularly those caused by MRSA, are a major health concern, highlighting the need for new antibacterial treatments derived from natural sources like arctic berries.
- This study assessed the antimicrobial effects of cloudberry and raspberry extracts on MRSA biofilms, finding that most extracts successfully inhibited biofilm development, except for a specific raspberry extract that was less effective.
- Although the berry extracts show promise in treating MRSA biofilms, there are some limitations that need to be considered for future applications.
Article Abstract
Introduction: Surgical site infection remains a devastating and feared complication of surgery caused mainly by (). More specifically, methicillin-resistant S. aureus (MRSA) infection poses a serious threat to global health. Therefore, developing new antibacterial agents to address drug resistance are urgently needed. Compounds derived from natural berries have shown a strong antimicrobial potential.
Methods: This study aimed to evaluate the effect of various extracts from two arctic berries, cloudberry () and raspberry (), on the development of an MRSA biofilm and as treatment on a mature MRSA biofilm. Furthermore, we evaluated the ability of two cloudberry seed-coat fractions, hydrothermal extract and ethanol extract, and the wet-milled hydrothermal extract of a raspberry press cake to inhibit and treat biofilm development in a wound-like medium. To do so, we used a model strain and two clinical strains isolated from infected patients.
Results: All berry extracts prevented biofilm development of the three MRSA strains, except the raspberry press cake hydrothermal extract, which produced a diminished anti-staphylococcal effect.
Discussion: The studied arctic berry extracts can be used as a treatment for a mature MRSA biofilm, however some limitations in their use exist.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327478 | PMC |
| http://dx.doi.org/10.3389/fcimb.2023.1176755 | DOI Listing |
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