AI Article Synopsis
- The study focused on the pathogen causing tularaemia, highlighting its significance as a global zoonotic threat and the need for consistent genome characterization to identify important genetic features.
- The analysis of genomes from two felines and one human revealed that 97.7% of genes were part of a core genome, with all isolates being classified as sequence type A based on genetic variations.
- Findings indicated that while most virulence genes were core components, an antibiotic resistance gene was present in all isolates, and phylogenetic comparisons showed similarities with other isolates from the Central and South-Central USA, emphasizing the importance of extensive genome analysis for understanding pathogen behavior and distribution.
Article Abstract
, the causative agent for tularaemia, is a Tier 1 select agent, and a pan-species pathogen of global significance due to its zoonotic potential. Consistent genome characterization of the pathogen is essential to identify novel genes, virulence factors, antimicrobial resistance genes, for studying phylogenetics and other features of interest. This study was conducted to understand the genetic variations among genomes of isolated from two felines and one human source. Pan-genome analysis revealed that 97.7 % of genes were part of the core genome. All three isolates were assigned to sequence type A based on single nucleotide polymorphisms (SNPs) in . Most of the virulence genes were part of the core genome. An antibiotic resistance gene coding for class A beta-lactamase was detected in all three isolates. Phylogenetic analysis showed that these isolates clustered with other isolates reported from Central and South-Central USA. Assessment of large sets of the genome sequences is essential in understanding pathogen dynamics, geographical distribution and potential zoonotic implications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323801 | PMC |
| http://dx.doi.org/10.1099/acmi.0.000451 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!