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Mitigating adverse outcomes in tuberculosis treatment: analyzing a non-compliance risk assessment strategy in a case report.
Rev Inst Med Trop Sao Paulo
October 2024
Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Article Synopsis
- Tuberculosis (TB) remains a significant global health threat, largely due to gaps in care that hinder effective treatment adherence, such as patient abandonment and irregular medication use.
- The article discusses a case of an immunocompetent patient with pulmonary TB who, despite following treatment protocols from 2017 to 2022, experienced treatment failures and ongoing health issues influenced by added complications like COVID-19 and pregnancy.
- This case emphasizes the necessity for holistic and patient-centered care strategies, including psychological support, especially for patients identified as high-risk, to improve TB management and outcomes effectively.
Abandon the Acid-Fast Bacilli Smear for Patients With TB on Effective Treatment.
Chest
July 2023
Pulmonary Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD. Electronic address:
Factors associated with directly observed treatment in tuberculosis/HIV coinfection cases in Porto Alegre, 2009-2013: A retrospective cohort.
PLoS One
March 2020
Department of Public Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Article Synopsis
- TB/HIV coinfection is a significant public health concern in Brazil, impacting patients' treatment adherence; Directly Observed Treatment (DOT) is recommended due to this vulnerability.
- A study conducted on TB/HIV patients in Porto Alegre from 2009 to 2013 revealed that only 16.9% received DOT, with various factors influencing its implementation, such as race, prior treatment outcomes, and social issues.
- The results showed a stark difference in mortality rates, with only 10.2% of deaths occurring in those who received DOT, highlighting its potential effectiveness in improving patient outcomes.
Prospective study on antimicrobial resistance in leprosy cases diagnosed in France from 2001 to 2015.
Clin Microbiol Infect
November 2018
AP-HP, Hôpital Lariboisière, Service de Bactériologie, Centre National de Référence des Mycobactéries et de la résistance des Mycobactéries aux Antituberculeux, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, INSERM, IAME UMR1137, Paris, France. Electronic address:
Antimicrobial resistance (AMR) in leprosy is mostly unknown because Mycobacterium leprae does not grow in vitro and bacteriologic investigations have been abandoned. However, molecular detection of resistance can be applied to multibacillary cases. Patients living in France mainland or in the French territories and diagnosed with leprosy from 2001 to 2015 were prospectively studied for AMR by detecting mutations in rpoB for rifampicin resistance, in folP1 for dapsone and in gyrA for ofloxacin.
View Article and Find Full Text PDF[Oral blastomycosis, laryngeal papillomatosis and esophageal tuberculosis].
Rev Peru Med Exp Salud Publica
June 2012
Hospital Regional del Cusco, Cusco, Perú.
Esophageal involvement is an extremely rare complication of tuberculosis even in countries with high prevalence of infection. We report the case of a 57 year-old hiv-seronegative patient with simultaneous diagnoses of oral blastomycosis and laryngeal papillomatosis. Both were confirmed by anatomopathological analysis.
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