Valproate overdose leading to hyperammonaemic encephalopathy.

BMJ Case Rep

Department of Research, School of Nursing and Midwifery, University of Birmingham, Edgbaston Campus, Birmingham, UK.

Published: July 2023

Sodium valproate is a commonly prescribed anticonvulsant medication; however, it can cause uncommon side effects such as hyperammonaemia and encephalopathy. We present the case of a male in his early 50s brought to the emergency department after being found collapsed by his wife, with an empty bottle of sodium valproate tablets. The patient developed hyperammonaemic encephalopathy due to sodium valproate overdose and was treated with supportive care and renal replacement therapy. This case highlights the importance of recognising the potential complications of sodium valproate and its prompt treatment.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335463PMC
http://dx.doi.org/10.1136/bcr-2023-255319DOI Listing

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