The aspiration for insight into human cognitive processing has traditionally driven research in cognitive science. With methods such as the Hidden semi-Markov Model-Electroencephalography (HsMM-EEG) method, new approaches have been developed that help to understand the temporal structure of cognition by identifying temporally discrete processing stages. However, it remains challenging to assign concrete functional contributions by specific processing stages to the overall cognitive process. In this paper, we address this challenge by linking HsMM-EEG with cognitive modelling, with the aim of further validating the HsMM-EEG method and demonstrating the potential of cognitive models to facilitate functional interpretation of processing stages. For this purpose, we applied HsMM-EEG to data from a mental rotation task and developed an ACT-R cognitive model that is able to closely replicate human performance in this task. Applying HsMM-EEG to the mental rotation experiment data revealed a strong likelihood for 6 distinct stages of cognitive processing during trials, with an additional stage for non-rotated conditions. The cognitive model predicted intra-trial mental activity patterns that project well onto the processing stages, while explaining the additional stage as a marker of non-spatial shortcut use. Thereby, this combined methodology provided substantially more information than either method by itself and suggests conclusions for cognitive processing in general.
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http://dx.doi.org/10.1016/j.neuropsychologia.2023.108615 | DOI Listing |
Prior research has indicated musicians show an auditory processing advantage in phonemic processing of language. The aim of the current study was to elucidate when in the auditory cortical processing stream this advantage emerges in a cocktail-party-like environment. Participants (n = 34) were aged 18-35 years and deemed to be either a musician (10+-year experience) or nonmusician (no formal training).
View Article and Find Full Text PDFEmerging evidence suggests that inhibitory control (IC) plays a pivotal role in science and maths counterintuitive reasoning by suppressing incorrect intuitive concepts, allowing correct counterintuitive concepts to come to mind. Neuroimaging studies have shown greater activation in the ventrolateral and dorsolateral pFCs when adults and adolescents reason about counterintuitive concepts, which has been interpreted as reflecting IC recruitment. However, the extent to which neural systems underlying IC support science and maths reasoning remains unexplored in children.
View Article and Find Full Text PDFJ Proteome Res
January 2025
Discovery Research, AbbVie, Inc., 1 North Waukegan Rd., North Chicago, Illinois 60064, United States.
Affinity capture (AC) combined with mass spectrometry (MS)-based proteomics is highly utilized throughout the drug discovery pipeline to determine small-molecule target selectivity and engagement. However, the tedious sample preparation steps and time-consuming MS acquisition process have limited its use in a high-throughput format. Here, we report an automated workflow employing biotinylated probes and streptavidin magnetic beads for small-molecule target enrichment in the 96-well plate format, ending with direct sampling from EvoSep Solid Phase Extraction tips for liquid chromatography (LC)-tandem mass spectrometry (MS/MS) analysis.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
January 2025
Faculty of Biotechnology and Food Sciences, Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Wolczanska 171/173, 90-530, Lodz, Poland.
In recent years, there has been a surge in the production of kombucha-a functional beverage obtained via microbial fermentation of tea. However, fresh, unpasteurized kombucha is sensitive to quality deterioration as a result of, among other factors, oxidation. The addition of hops seems to be promising, due to their antioxidative properties, which may improve the stability of kombucha.
View Article and Find Full Text PDFMater Horiz
January 2025
Key Laboratory of Polymer Processing Engineering of the Ministry of Education, National Engineering Research Center of Novel Equipment for Polymer Processing, Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, South China University of Technology, Guangzhou 510641, People's Republic of China.
Passive daytime radiative cooling offers a promising approach to address energy, environmental, and safety issues caused by global warming. However, the contradiction between high radiative cooling performance and long-lasting ultraviolet (UV) durability is a primary limitation at the current stage. Here, inspired by the ability of epidermal cells and palisade cells on the leaf surface to protect internal leaf structures (such as chloroplasts and nuclei) under drought and high-temperature conditions, a double-layer passive radiative cooling (PRC) porous membrane, which consists of an upper protective layer densely packed with highly ultraviolet-reflective inorganic particles and a bottom cooling layer doped with a variety of optically characterized inorganic particles, was developed to overcome these challenges.
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