Introduction: Stauffer's syndrome is a rare paraneoplastic non metastatic hepatic dysfunction related to renal cell carcinoma. It is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate, a-2-globulin, y-glutamyl transferase, thrombocytosis, prolongation of prothrombin time and hepatosplenomegaly, in the absence of hepatic metastasis. A rare variant of it with cholestatic jaundice is described in four cases so far in literature.

Clinical Presentation: We present a case of a patient presented with features of cholestatic jaundice who was found to have a left sided renal cell carcinoma in the work up.

Discussion: This case illustrates the importance of considering paraneoplastic syndromes in mind when working up for patients presenting with hepatic dysfunctions without identifiable causes.

Conclusion: This may result in early identification and intervention which will result in better outcome and prolong survival rate.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382848PMC
http://dx.doi.org/10.1016/j.ijscr.2023.108455DOI Listing

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