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Temperature regulation in dogs is significantly impaired during general anesthesia. Glabrous skin on paws may facilitate thermoregulation from this area and is a potential target for interventions attenuating hypothermia. This pilot study aimed to compare efficacy of an innovative warming device placed on the front paws (AVAcore; AVA), with no warming methods (NONE) and conventional truncal warming methods (CONV; circulating water blanket/forced air warmer) on rectal temperature and anesthetic recovery times.

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Assessing Facial Thermal Nociceptive Response in Female Dogs After Elective Ovariohysterectomy Anesthetized with Isoflurane and Treated with Cannabidiol and Meloxicam Analgesia.

Animals (Basel)

January 2025

Neurophysiology of Pain, Behavior and Assessment of Welfare in Domestic Animals, Department of Animal Production and Agriculture, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, Mexico.

Pain management requires the identification of certain indicators to recognize pain. Various tools have been suggested to achieve an objective evaluation, including infrared thermography (IRT). The objective of this study was to assess the facial thermal nociceptive response produced by the use of cannabidiol (CBD) alone and in combination with meloxicam in female dogs undergoing elective ovariohysterectomy anesthetized with isoflurane.

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Background: Anesthesia can significantly impact positron emission tomography (PET) neuroimaging in preclinical studies. Therefore, understanding these effects is crucial for accurate interpretation of the results. In this experiment, we investigate the effect of [F]-labeled glucose analog fluorodeoxyglucose ([F]FDG) uptake in the brains of rats anesthetized with two commonly used anesthetics for rodents: isoflurane, an inhalation anesthetic, and Hypnorm-Dormicum, a combination injection anesthetic.

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Identification of hypothermia-inducing neurons in the preoptic area and activation of them by isoflurane anesthesia and central injection of adenosine.

J Physiol Sci

January 2025

Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8-35-1, 890-8544, Kagoshima, Japan. Electronic address:

Hibernation and torpor are not passive responses caused by external temperature drops and fasting but are active brain functions that lower body temperature. A population of neurons in the preoptic area was recently identified as such active torpor-regulating neurons. We hypothesized that the other hypothermia-inducing maneuvers would also activate these neurons.

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Article Synopsis
  • Anesthetic gases are linked to global warming, prompting a project to analyze their carbon dioxide equivalent (CDE) production and fresh gas flows (FGF) in the operating room over two years.
  • In the second year, individualized feedback through a dashboard significantly reduced median FGF from 2.0 to 1.9 l/min and total CDE from 5.10 to 3.59 kg/hr (both p < 0.001).
  • The intervention resulted in notable reductions in CDE for isoflurane and nitrous oxide, leading to faster declines in their usage rates, although it showed no significant impact on sevoflurane or nitrous oxide CDE rates.
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