AI Article Synopsis
- IL-33 is a cytokine that activates Th2 immune responses, triggering pathways that can help protect against cardiovascular diseases (CVDs) by promoting M2 macrophage polarization.
- However, the presence of soluble ST2 (sST2) can bind to IL-33 and reduce its protective effects, potentially worsening CVD outcomes.
- This review highlights IL-33's protective role in CVDs and suggests that sST2 could serve as a diagnostic biomarker, positioning IL-33 as a potential target for therapeutic intervention in cardiovascular health.
Article Abstract
IL-33 belongs to the IL-1 family of cytokines, which function as inducers of Th2 cytokine production by binding with ST2L and IL-1RAcP. This, in turn, activates various signaling pathways, including the mitogen-activated protein kinase (MAPK), the inhibitor of Kappa-B kinase (IKK) pathway, and the phospholipase D-sphingosine kinase pathway. IL-33 has demonstrated protective effects against various cardiovascular diseases (CVDs) by inducing Th2 cytokines and promoting alternative activating M2 polarization. However, the soluble decoy form of ST2 (sST2) mitigates the biological effects of IL-33, exacerbating CVDs. Furthermore, IL-33 also plays a significant role in the development of asthma, arthritis, atopic dermatitis, and anaphylaxis through the activation of Th2 cells and mast cells. In this review, we aim to demonstrate the protective role of IL-33 against CVDs from 2005 to the present and explore the potential of serum soluble ST2 (sST2) as a diagnostic biomarker for CVDs. Therefore, IL-33 holds promise as a potential therapeutic target for the treatment of CVDs.
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| http://dx.doi.org/10.1016/j.cytogfr.2023.06.003 | DOI Listing |
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