Cancer is an abnormal proliferation of cells in a tissue or organ that causes the cells to change their nature, eventually producing a lump or mass and spreading to other regions of the body in most cases. The purpose of this study is to evaluate the level of coenzyme Q 10 in breast cancer patients and to determine their relationship to the proliferation of breast cancer. This study has investigated 90 women (60 patients and 30 controls) subdivided according to stages of cancer status. This study shows the mean of coenzyme Q 10 was observed in breast cancer women (16.91±2.52) as compared with the healthy control group (42.49±7.45) the difference was highly significant at a P. value of 0.0003. The mean and stander deviation of coenzyme Q 10 in women with breast cancer (stage 1, stage2, stage3, and metastatic stage) were (28.03b±5.81, 17.51b±3.42, 22.71b±4.38, and 17.93b±2.92) in comparison with healthy women were(40.22a±3.13). It was concluded that the levels of coenzyme Q 10 were significantly decreased in breast cancer women as compared with healthy women.
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East Mediterr Health J
December 2024
Department of Radiology, King Abdulaziz University, Jeddah, Saudi Arabia.
Background: Breast cancer is often thought to occur at a younger age among Arab women based on the mean or median age at diagnosis, or the proportion of women diagnosed with breast cancer at a young age.
Objective: To compare age-specific breast cancer incidence rates among women from selected Arab countries with selected high- and middle-income countries.
Methods: We examined population-based, age-specific, national or regional breast cancer incidence data for 2008-2012 and 2013-2017 from Australia, Brazil, Canada, Germany, Japan, United Kingdom, and United States of America, and compared them with data from Algeria, Bahrain, Jordan, Kuwait, Morocco, Qatar, and Saudi Arabia.
Pharm Dev Technol
January 2025
Department of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance hydrogen spectrum (H-NMR). Pharmacokinetic results showed that the accumulation of QUE in plasma of the NPC-QUE-L group was 1.
View Article and Find Full Text PDFJ Med Econ
January 2025
UNESCO-TWAS, The World Academy of Sciences, Trieste, Italy.
Aim: Dynamic cancer control is a current health system priority, yet methods for achieving it are lacking. This study aims to review the application of system dynamics modeling (SDM) on cancer control and evaluate the research quality.
Methods: Articles were searched in PubMed, Web of Science, and Scopus from the inception of the study to November 15th, 2023.
Int J Surg
January 2025
Computer Science and Technology, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Detection of biomarkers of breast cancer incurs additional costs and tissue burden. We propose a deep learning-based algorithm (BBMIL) to predict classical biomarkers, immunotherapy-associated gene signatures, and prognosis-associated subtypes directly from hematoxylin and eosin stained histopathology images. BBMIL showed the best performance among comparative algorithms on the prediction of classical biomarkers, immunotherapy related gene signatures, and subtypes.
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