INVESTIGATION OF THE LEVEL OF MONOSACCHARIDES IN SALIVA OF PATIENTS WITH IMPAIRED CARBOHYDRATE METABOLISM.

Carbohydrate metabolism disorder is a severe systemic disease leading to the development of a full range of metabolic disorders, accompanied by obesity, vascular pathology, connective tissue damage. Therefore, a range of activities is very important for such patients, which allows you to reduce blood glucose levels. These procedures include dietary nutrition, moderate load, reduced stress, and, if necessary, gastric surgery is performed to reduce food drive, and, as a result, reduced body weight. Objective - investigate glucose, fructose, and galactose levels in saliva of patients with impaired carbohydrate metabolism and establish a relationship with blood plasma parameters. Saliva samples obtained from 38 patients: patients with DM-2, patients with DM-2 and obesity after bariatric surgery, patients with prediabetes, obesity, and impaired glucose tolerance. The control group made up of healthy volunteers who denied having somatic pathology. Within the framework of the study, a protocol was formed containing the values of anthropometric indices and assessments of body parameters, the results of the study of lipid and carbohydrate spectrum parameters in plasma. Saliva samples calculated for salivation rate, saliva pH, and glucose, fructose, and galactose in μg/ml determined by high-liquid chromatography. Showed that saliva of patients with diabetes mellitus type 2 showed significantly (p<0.05) low level of fructose, patients with glucose tolerance significantly (p<0.05) high galactose content, and patients with diabetes mellitus type 2 after bariatric surgery maximum (p<0.05) amount of glucose. In saliva, the content of monosaccharides is determined, but their amount is small and requires the use of highly sensitive methods. Differences in the quantitative and qualitative content of monosaccharides in saliva are determined by the type of carbohydrate metabolism disorder.