In this meet-the-author Q&A, Cell Press Community Review editor Leslie Nitsche speaks to Eric Ortlund as well as Eva Huber and Michael Groll from the Groll group about their recent Structure papers and their experiences publishing via Cell Press Community Review.
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| http://dx.doi.org/10.1016/j.str.2023.06.003 | DOI Listing |
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Effects of DHEA and DHEAS in Neonatal Hypoxic-Ischemic Brain Injury.
Antioxidants (Basel)
December 2024
Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Neonatal brain injury remains a significant issue with limited treatment options. This study investigates the potential of the endogenous neurosteroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) as neuroprotective agents, building on evidence of their mechanisms in adult brain injury models. The primary objective was to evaluate their neuroprotective and anti-oxidative properties in a mouse model of neonatal hypoxic-ischemic brain injury.
View Article and Find Full Text PDFIsofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification.
Angew Chem Int Ed Engl
December 2024
Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, 35043, Marburg, Germany.
Dithiolopyrrolone (DTP) natural products are produced by several different bacteria and have potent antibacterial, antifungal and anticancer activities. While the amide of their DTP core can be methylated to fine-tune bioactivity, the enzyme responsible for the amide N-methylation has remained elusive in most taxa. Here, we identified the amide methyltransferase XrdM that is responsible for xenorhabdin (XRD) methylation in Xenorhabdus doucetiae but encoded outside of the XRD gene cluster.
View Article and Find Full Text PDFFactors Influencing Breast Milk Antibody Titers during the Coronavirus Disease 2019 Pandemic: An Observational Study.
Nutrients
July 2024
Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
The COVID-19 pandemic has highlighted the role of breastfeeding in providing passive immunity to infants via specific anti-SARS-CoV-2 antibodies in breast milk. We aimed to quantify these antibodies across different lactation stages and identify influencing factors. This prospective study involved mother-child dyads from Innsbruck University Hospital, Austria, with a positive maternal SARS-CoV-2 test during pregnancy or peripartum between 2020 and 2023.
View Article and Find Full Text PDFYoung hearts, early risks: novel cardiovascular biomarkers in former very preterm infants at kindergarten age.
Pediatr Res
September 2024
Department of Pediatrics II, Medical University of Innsbruck, Innsbruck, Austria.
Background: Preterm birth is associated with long-term cardiovascular morbidity and mortality. In adults, fibroblast growth factor-23 (FGF-23), α-Klotho, and secretoneurin have all garnered attention as cardiovascular biomarkers, but their utility in pediatric populations has not yet been ascertained. The aim of this pilot study was to evaluate these novel cardiovascular biomarkers and their association with indicators of cardiovascular impairment in the highly vulnerable population of former very preterm infants.
View Article and Find Full Text PDFSurprisal From Language Models Can Predict ERPs in Processing Predicate-Argument Structures Only if Enriched by an Agent Preference Principle.
Neurobiol Lang (Camb)
April 2024
Department of Comparative Language Science, University of Zurich, Zurich, Switzerland.
Language models based on artificial neural networks increasingly capture key aspects of how humans process sentences. Most notably, model-based surprisals predict event-related potentials such as N400 amplitudes during parsing. Assuming that these models represent realistic estimates of human linguistic experience, their success in modeling language processing raises the possibility that the human processing system relies on no other principles than the general architecture of language models and on sufficient linguistic input.
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