AI Article Synopsis
- - This study compared early and delayed FDG PET/CT scans' effectiveness in diagnosing cardiac sarcoidosis in 23 patients who followed a specific diet to minimize heart activity.
- - Results showed that while 91.3% of patients had detectable heart activity in early scans, 100% showed activity in delayed scans, with delayed scans demonstrating significantly higher uptake in heart lesions.
- - The findings indicate that delayed acquisition scans offer better detection accuracy for cardiac sarcoidosis, as they reduce interference from blood pool activity, leading to a more reliable assessment.
Article Abstract
Objective: This study aimed to compare the contribution of F-fluorodepxyglucose (FDG) positron (PET)/ computed tomography (CT) acquisition of early and delayed scans in patients with cardiac sarcoidosis (CS).
Methods: Twenty-three patients with CS (median age: 69 years; 11 women) were retrospectively evaluated using dual-phase FDG PET/CT. All patients were instructed to consume a low-carbohydrate diet followed by fasting for 18 h before FDG injection to reduce physiological myocardial uptake. PET/CT was acquired at 60 min (early) and 100 min (delayed) after FDG administration. Focal and focal on diffuse uptake on visual analysis was considered positive for CS. A semi-quantitative analysis was performed using the maximum standardized uptake value (SUVmax) of the cardiac lesion and the mean SUV (SUVmean) of the blood pool.
Results: Significant myocardial FDG uptake was observed in 21 patients (91.3%) in the early acquisition group and in 23 patients in the delayed scan group (100%). Compared to the early scan, the delayed scan showed a significantly higher SUVmax of the cardiac lesion [median, 4.0; IQR (interquartile range, 2.9 to 7.0) vs. 5.8 (IQR 3.7 to 10.1); P = 0.0030] and a significantly lower SUVmean of blood pool [median, 1.3 (IQR, 1.2 to 1.4) vs. 1.1 (IQR, 0.9 to 1.2); P < 0.0001].
Conclusion: Delayed FDG PET/CT acquisition improves detection accuracy in patients with CS compared to early scans with washout of the blood pool activity. Therefore, it can contribute to a more accurate assessment of CS.
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| http://dx.doi.org/10.1007/s12149-023-01855-8 | DOI Listing |
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