Major depression is a severe psychological disorder typically diagnosed using scale tests and through the subjective assessment of medical professionals. Along with the continuous development of machine learning techniques, computer technology has been increasingly employed to identify depression in recent years. Traditional methods of automatic depression recognition rely on using the patient's physiological data, such as facial expressions, voice, electroencephalography (EEG), and magnetic resonance imaging (MRI) as input. However, the acquisition cost of these data is relatively high, making it unsuitable for large-scale depression screening. Thus, we explore the possibility of utilizing a house-tree-person (HTP) drawing to automatically detect major depression without requiring the patient's physiological data. The dataset we used for this study consisted of 309 drawings depicting individuals at risk of major depression and 290 drawings depicting individuals without depression risk. We classified the eight features extracted from HTP sketches using four machine-learning models and used multiple cross-validations to calculate recognition rates. The best classification accuracy rate among these models reached 97.2%. Additionally, we conducted ablation experiments to analyze the association between features and information on depression pathology. The results of Wilcoxon rank-sum tests showed that seven of the eight features significantly differed between the major depression group and the regular group. We demonstrated significant differences in HTP drawings between patients with severe depression and everyday individuals, and using HTP sketches to identify depression automatically is feasible, providing a new approach for automatic identification and large-scale screening of depression.
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http://dx.doi.org/10.1080/10255842.2023.2231113 | DOI Listing |
Clin EEG Neurosci
March 2025
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Major depressive disorder (MDD) is a disorder with multiple impairments, among which emotion disorder is the most main one. Nowadays, evoked activity (EA), such as event-related potential (ERP), has mostly been studied for MDD, but induced activity (IA) analysis is still lacking. In this paper, EA, IA and event-related spectral perturbation (ERSP) were studied and compared between MDD patients and healthy controls (HC).
View Article and Find Full Text PDFCan J Psychiatry
March 2025
Department of Psychiatry, University of Oxford, Oxford, UK.
ObjectiveWe summarize the key steps to develop and assess an innovative online, evidence-based tool that supports shared decision-making in routine care to personalize antidepressant treatment in adults with depression. This PETRUSHKA tool is part of the PETRUSHKA trial (Personalize antidEpressant Treatment foR Unipolar depreSsion combining individual cHoices, risKs, and big datA).MethodsThe PETRUSHKA tool: (a) is based on prediction models, which use a combination of advanced analytics, i.
View Article and Find Full Text PDFHealth Technol Assess
March 2025
Clinical Trials Research Unit, University of Leeds, Leeds, UK.
Background: Many patients with ulcerative colitis report ongoing diarrhoea even when their disease is stable and in remission.
Design: MODULATE was a pragmatic, multicentre, seamless, adaptive, phase 2/3 open-label, parallel-group, multiarm multistage randomised controlled trial.
Setting And Participants: People aged over 18 years with stable ulcerative colitis who had diarrhoea, recruited from secondary care sites in the United Kingdom.
Brain Behav
March 2025
Department of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China.
Purpose: Structural changes during depressive episodes in adolescents with major depressive disorder (MDD) remains unclear due to participant heterogeneity, illness chronicity, and medication confounders. This study aimed to explore white matter (WM) microstructural changes in first-episode, treatment-naïve adolescents with MDD using an integrated diffusion tensor imaging (DTI) approach.
Method: We recruited 66 subjects, including 37 adolescents with MDD and 29 healthy controls.
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