A microbial ecosystem is a complex community of multiple bacterial interactions. The potential role of gut microbiota in human health has already attracted the attention of many researchers. Dysregulation of the gut microbial community has been suggested to be closely associated with the progression of various chronic diseases. Malignant neoplasms represent a major global health burden and are now the leading cause of death. The formation of tumors is often thought to be influenced by genetic and environmental factors. Recent research advances have indicated that multiple malignancies may also be attributed to the gut microbiota. In this review, we highlight the complex interactions between gut microbes and their metabolites, as well as the potential impact of gut microecology on the occurrence and development of tumors. In addition, potential strategies for targeted therapy of tumors using gut microecology are discussed. In the near future, intestinal microecology is likely to be used for early screening of tumors and subsequent clinical treatment.
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http://dx.doi.org/10.1097/MD.0000000000034274 | DOI Listing |
Hepatobiliary Pancreat Dis Int
December 2024
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Jinan Microecological Biomedicine Shandong Laboratory, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou 310000, China. Electronic address:
Background: Coronavirus disease 2019 (COVID-19) is a global pandemic with high mortality, and the treatment options for the severe patients remain limited. Previous studies reported the altered gut microbiota in severe COVID-19. But there are no comprehensive data on the role of microbial metabolites in COVID-19 patients.
View Article and Find Full Text PDFJ Adv Res
December 2024
Department of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Inflammatory Bowel Disease Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Division of Gastroenterology and Hepatology, Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Introduction: In Crohn's disease (CD), lesions are mainly distributed in a segmental manner, with the primary sites of involvement being the ileum and colon. Heterogeneity in colon and ileum results in location-specific clinical presentations and therapeutic responses. Mucosal healing tends to be more readily and quickly achieved in the colon than in the ileum, where lesions are more likely to develop into complex behaviors.
View Article and Find Full Text PDFZhongguo Yi Xue Ke Xue Yuan Xue Bao
December 2024
Department of Bariatric and Metabolic Surgery,Beijing Friendship Hospital, Capital Medical University,Beijing 100050,China.
The pathogenesis of obesity-associated kidney disease (OAKD) involves many aspects,including the overactivation of the renin-angiotensin-aldosterone system,insulin resistance,chronic inflammation,disorder of lipid metabolism and imbalance of gut microecology.Treatment strategies for OAKD focus on lifestyle adjustments,pharmacotherapy,bariatric surgery,and fecal microbiota transplantation.A deeper understanding of the hazards of OAKD and its pathogenesis will contribute to the development of personalized and precise strategies for prevention,diagnosis and treatment of OAKD in the future.
View Article and Find Full Text PDFJ Agric Food Chem
December 2024
College of Veterinary Medicine, Jilin Agricultural University, Changchun, Jilin 130018, China.
Sauerkraut contains various fermentative microorganisms that produce active metabolites, enhancing immunity and resistance to infections. However, its effects on methicillin-resistant (MRSA)-induced acute lung injury (ALI) remain unclear. Using RAW264.
View Article and Find Full Text PDFFront Cell Infect Microbiol
December 2024
Medical Laboratory, Kunming Children's Hospital, Children's Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China.
Sepsis is a systemic inflammatory response syndrome of multiorgan failure caused by dysregulation of the host response to infection and is a major cause of death in critically ill patients. In recent years, with the continuous development of sequencing technology, the intestinal microecology of this disease has been increasingly studied. The gut microbiota plays a host-protective role mainly through the maintenance of normal immune function and the intestinal barrier.
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