AI Article Synopsis
- Recent trials show that the oral antiviral VV116 might be effective for treating mild COVID-19, but its safety and efficacy haven't been thoroughly studied.
- A systematic review identified three key studies indicating no serious side effects from VV116, with patients experiencing viral shedding 2.57 days faster than those in the control group and showing similar improvements in symptoms compared to the standard treatment.
- Despite promising results, the limited number of trials and the focus on younger patients suggest the need for more research, especially involving older populations or those with severe COVID-19 cases for a better understanding of VV116's effectiveness.
Article Abstract
Background: Recent trials have highlighted the potential of oral antiviral VV116 in the treatment of patients with mild COVID-19. However, no comprehensive studies have assessed the safety and efficacy of VV116. Therefore, we conducted a systematic review to assess the safety and efficacy of VV116.
Methods: A comprehensive search was conducted on PubMed, Scopus, and Google Scholar websites, with a cutoff date of March 23, to identify pertinent studies.
Results: The results from the 3 included studies indicated that no serious adverse events were reported in the VV116 experimental groups, which exhibited a 2.57-day faster time to viral shedding than the control group and demonstrated non-inferiority to the nirmatrelvir-ritonavir control group in alleviating major symptoms.
Discussion: Collectively, available studies suggest a reliable safety and efficacy profile for VV116. However, the limited number of trials was insufficient for meta-analysis, and the included population consisted of younger individuals with mild and moderate symptoms, not encompassing the elderly who are severely affected by COVID-19. We hope that more studies will be conducted in the future to ensure that VV116 has a more reliable safety and efficacy profile in the clinical setting, especially in severe or critical patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328638 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000034105 | DOI Listing |
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