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| http://dx.doi.org/10.3988/jcn.2022.0433 | DOI Listing |
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MRI-Negative Central Nervous System SLE: A Unique Case Report.
Ann Indian Acad Neurol
December 2024
Department of Neurology, Institute of Human Behaviour and Allied Science, Delhi, India.
Article Synopsis
- Hippocampal sclerosis (HS) is a major cause of temporal lobe epilepsy (TLE) but can be hard to detect on MRI, leading to surgical delays, so researchers created open-source software to improve diagnosis.
- The study involved 365 participants, using the software HippUnfold to analyze MRI scans and develop a logistic regression model that accurately identifies and localizes HS.
- The classifier showed high accuracy in detecting HS in both initial and independent patient cohorts, proving effective for individual assessments by comparing patient data with normative growth patterns.
Multimodal and quantitative analysis of the epileptogenic zone network in the pre-surgical evaluation of drug-resistant focal epilepsy.
Neurophysiol Clin
November 2024
Department of Neurosciences, Mater Misericordiae Hospital, Brisbane, Queensland, Australia; Mater Research Institute, Faculty of Medicine, University of Queensland, Australia; Queensland Brain Institute, University of Queensland, Australia.
Surgical resection for epilepsy often fails due to incomplete Epileptogenic Zone Network (EZN) localization from scalp electroencephalography (EEG), stereo-EEG (SEEG), and Magnetic Resonance Imaging (MRI). Subjective interpretation based on interictal, or ictal recordings limits conventional EZN localization. This study employs multimodal analysis using high-density-EEG (HDEEG), Magnetoencephalography (MEG), functional-MRI (fMRI), and SEEG to overcome these limitations in a patient with drug-resistant MRI-negative focal epilepsy.
View Article and Find Full Text PDFAnti-dopamine receptor 2 antibody encephalitis in adults: a case report.
BMC Neurol
October 2024
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou City, Henan Province, 450052, People's Republic of China.
Background: Anti-dopamine receptor 2 (D2R) antibody encephalitis (D2R encephalitis) is a subtype of autoimmune encephalitis (AE). Lesions in affected patients primarily involve the basal ganglia, resulting in a range of psychiatric and movement disorders. A majority of cases reported to date have impacted children or adolescents, whereas we here describe a case of adult-onset D2R encephalitis.
View Article and Find Full Text PDFVPS13C and STING expression in neuropsychiatric systemic lupus erythematosus: unveiling an unbreached territory.
Lupus Sci Med
September 2024
Clinical Pathology Department, Zagazig University Faculty of Human Medicine, Zagazig, Sharkia, Egypt.
Objectives: To measure the expression level of the vacuolar protein sorting 13 (VPS13) gene and stimulator of interferon genes (STING) in patients with SLE with and without reported neuropsychiatric symptoms to establish their possible role in the pathogenesis of neuropsychiatric SLE (NPSLE).
Methods: This study included 100 subjects: 50 patients diagnosed with SLE and 50 age-matched and sex-matched healthy participants as the control group. The patients with SLE were further subdivided into NPSLE and non-NPSLE groups.
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