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Esophageal stent dysfunction: unclogging the Red Sea.
Rev Esp Enferm Dig
June 2024
Gastroenterology , Unidade Local de Saúde de Lisboa Ocidental, Portugal.
Self-expandable metal stents (SEMS) have been widely used for the palliation of esophageal malignant dysphagia. Stent-related dysphagia is frequent and should raise the suspicion of stent migration, tumor ingrowth or overgrowth. In addition, bleeding has been reported in nearly 7% of patients.
View Article and Find Full Text PDFOrofacial Anomalies in Kindler Epidermolysis Bullosa.
JAMA Dermatol
May 2024
Department of Dermatology, Medical Faculty and Medical Center, University of Freiburg, Freiburg, Germany.
Importance: Kindler epidermolysis bullosa is a genetic skin-blistering disease associated with recessive inherited pathogenic variants in FERMT1, which encodes kindlin-1. Severe orofacial manifestations of Kindler epidermolysis bullosa, including early oral squamous cell carcinoma, have been reported.
Objective: To determine whether hypoplastic pitted amelogenesis imperfecta is a feature of Kindler epidermolysis bullosa.
HPV related p16 and HSV in benign and potentially malignant oral mucosa pathologies.
BMC Oral Health
March 2024
Oral Pathology Department, Faculty of Dentistry, Wroclaw Medical University, Ul. Krakowska 26, Wroclaw, 50-425, Poland.
Background: The association of Human Papilloma Virus (HPV) and Human Syncytial Virus (HSV) infection with inflammatory and potentially malignant disorders of the oral cavity (OPMD) is unknown. The aim of this cross-sectional study was to stablish the expression of the p16 and HSV proteins, to test potential correlation between those parameters in biopsies from clinically diagnosed oral lesions.
Methods: Immunochemical analysis of 211 formalin-fixed, paraffin-embedded (FFPE) blocks from 211 individuals was provided.
The incidence and management of complications following stenting of oesophageal malignancies.
S Afr J Surg
November 2023
Surgical Gastroenterology, Department of Surgery, Groote Schuur Hospital, University of Cape Town.
Background: Oesophageal stenting effectively palliates malignant dysphagia with reported high technical and clinical success rates approaching 90% and a low, though often problematic, complication frequency. This study aimed to benchmark success rates, the incidence and management of complications at a tertiary interventional endoscopy centre.
Methods: This single centre three-year (March 2018-March 2021) study reviewed demographics, tumour histology/ position, and early and late complications of palliative oesophageal stenting.
Hippo cooperates with p53 to maintain foregut homeostasis and suppress the malignant transformation of foregut basal progenitor cells.
Proc Natl Acad Sci U S A
March 2024
State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Basal progenitor cells serve as a stem cell pool to maintain the homeostasis of the epithelium of the foregut, including the esophagus and the forestomach. Aberrant genetic regulation in these cells can lead to carcinogenesis, such as squamous cell carcinoma (SCC). However, the underlying molecular mechanisms regulating the function of basal progenitor cells remain largely unknown.
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