One consistent finding in the causal reasoning literature is that causal judgments are rather variable. In particular, distributions of probabilistic causal judgments tend not to be normal and are often not centered on the normative response. As an explanation for these response distributions, we propose that people engage in 'mutation sampling' when confronted with a causal query and integrate this information with prior information about that query. The Mutation Sampler model (Davis & Rehder, 2020) posits that we approximate probabilities using a sampling process, explaining the average responses of participants on a wide variety of tasks. Careful analysis, however, shows that its predicted response distributions do not match empirical distributions. We develop the Bayesian Mutation Sampler (BMS) which extends the original model by incorporating the use of generic prior distributions. We fit the BMS to experimental data and find that, in addition to average responses, the BMS explains multiple distributional phenomena including the moderate conservatism of the bulk of responses, the lack of extreme responses, and spikes of responses at 50%.
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http://dx.doi.org/10.1162/opmi_a_00080 | DOI Listing |
Environ Sci Technol
January 2025
Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.
Pet dogs offer valuable models for studying environmental impacts on human health due to shared environments and a shorter latency period for cancer development. We assessed environmental chemical exposures in a case-control study involving dogs at high risk of urothelial carcinoma, identified by a BRAF V595E mutation in urinary epithelial cells. Cases ( = 25) exhibited low-level BRAF mutations, while controls ( = 76) were matched dogs without the mutation.
View Article and Find Full Text PDFJ Exp Psychol Learn Mem Cogn
September 2024
Causes sometimes decrease rather increase the probability of an effect, as when drinking coffee lowers the probability of sleep or an aspirin eliminates a headache. This research tests how two causal reasoning errors that have influenced the development of theories of human causal reasoning manifest themselves in the presence of inhibitory causal relations. Past research with generative causal relations (a cause makes its effect more probable) has shown that people violate the Markov condition, the pattern of independence that should obtain among causally related variables.
View Article and Find Full Text PDFCurr Genomics
May 2024
Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Background: Single Amino Acid Polymorphisms (SAPs) or nonsynonymous Single Nucleotide Variants (nsSNVs) are the most common genetic variations. They result from missense mutations where a single base pair substitution changes the genetic code in such a way that the triplet of bases (codon) at a given position is coding a different amino acid. Since genetic mutations sometimes cause genetic diseases, it is important to comprehend and foresee which variations are harmful and which ones are neutral (not causing changes in the phenotype).
View Article and Find Full Text PDFStat Med
December 2023
Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
PLoS Comput Biol
August 2023
Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America.
Inferring dependencies between mixed-type biological traits while accounting for evolutionary relationships between specimens is of great scientific interest yet remains infeasible when trait and specimen counts grow large. The state-of-the-art approach uses a phylogenetic multivariate probit model to accommodate binary and continuous traits via a latent variable framework, and utilizes an efficient bouncy particle sampler (BPS) to tackle the computational bottleneck-integrating many latent variables from a high-dimensional truncated normal distribution. This approach breaks down as the number of specimens grows and fails to reliably characterize conditional dependencies between traits.
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